Microbial memories: Sex-dependent impact of the gut microbiome on hippocampal plasticity,European Journal of Neuroscience

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Microbial memories: Sex-dependent impact of the gut microbiome on hippocampal plasticity
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2021-01-18 , DOI: 10.1111/ejn.15119
Henry T. Darch ₁ , Michael K. Collins ₁ , Ken J. O’Riordan ₁ , John F. Cryan _{1,

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Affiliation

Germ-free rodents, raised in the absence of a measurable gut microbiome, have been a key model to study the microbiome-gut-brain axis. Germ-free mice exhibit marked behavioural and neurochemical differences to their conventionally raised counterparts. It is as yet unclear how these neurochemical differences lead to the behavioural differences. Here, we test the electrophysiological properties of hippocampal plasticity in adult germ-free mice and compare them to conventionally raised counterparts. Whilst basal synaptic efficacy and pre-synaptic short-term plasticity appear normal, we find a striking alteration of hippocampal long-term potentiation specifically in male germ-free slices. However, the spike output of these neurons remains normal along with altered input-output coupling, potentially indicating homeostatic compensatory mechanisms, or an altered excitation/inhibition balance. To our knowledge this is the first time the electrophysiological properties of the hippocampus have been assessed in a microbiome deficient animal. Our data indicate that the absence of a microbiome alters integration of dendritic signalling in the CA1 region in mice.

中文翻译：

微生物记忆：肠道微生物群对海马体可塑性的性别依赖性影响

在没有可测量的肠道微生物组的情况下饲养的无菌啮齿动物一直是研究微生物组 - 肠 - 脑轴的关键模型。无菌小鼠与其常规饲养的小鼠表现出显着的行为和神经化学差异。目前尚不清楚这些神经化学差异如何导致行为差异。在这里，我们测试成年无菌小鼠海马可塑性的电生理特性，并将它们与常规饲养的对应物进行比较。虽然基础突触功效和突触前短期可塑性看起来正常，但我们发现海马长期增强的显着改变，特别是在男性无菌切片中。然而，这些神经元的尖峰输出随着输入-输出耦合的改变而保持正常，这可能表明稳态补偿机制，或改变的激发/抑制平衡。据我们所知，这是第一次在缺乏微生物组的动物中评估海马体的电生理特性。我们的数据表明，微生物组的缺失改变了小鼠 CA1 区域树突信号的整合。

更新日期：2021-01-18

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