Engineering Oxygen‐Irrelevant Radical Nanogenerator for Hypoxia‐Independent Magnetothermodynamic Tumor Nanotherapy,Small Methods

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Engineering Oxygen‐Irrelevant Radical Nanogenerator for Hypoxia‐Independent Magnetothermodynamic Tumor Nanotherapy
Small Methods ( IF 10.7 ) Pub Date : 2021-01-18 , DOI: 10.1002/smtd.202001087
Yujia Shen ₁ , Caihong Dong ₁ , Huijing Xiang ₂ , Cuixian Li ₁ , Fan Zhuang ₁ , Yixin Chen ₁ , Qing Lu ₁ , Yu Chen ₂ , Beijian Huang ₁

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Tumor hypoxia substantially lowers the treatment efficacy of oxygen‐relevant therapeutic modalities because the production of reactive oxygen species in oxygen‐relevant anticancer modalities is highly dependent on oxygen level in tumor tissues. Here a distinctive magnetothermodynamic anticancer strategy is developed that takes the advantage of oxygen‐irrelevant free radicals produced from magnetothermal decomposable initiators for inducing cancer‐cell apoptosis in vitro and tumor suppression in vivo. Free‐radical nanogenerator is constructed through in situ engineering of a mesoporous silica coating on the surface of superparamagnetic Mn and Co‐doped nanoparticles (MnFe₂O₄@CoFe₂O₄, denoted as Mag) toward multifunctionality, where mesoporous structure provides reservoirs for efficient loading of initiators and the Mag core serves as in situ heat source under alternating magnetic field (AMF) actuation. Upon exposure to an exogenous AMF, the magnetic hyperthermia effect of superparamagnetic core lead to the rapid decomposition of the loaded/delivered initiators (AIPH) to produce oxygen‐irrelevant free radicals. Both the magnetothermal effect and generation of toxic free radicals under AMF actuation are synergistically effective in promoting cancer‐cell death and tumor suppression in the hypoxic tumor microenvironment. The prominent therapeutic efficacy of this radical nanogenerator represents an intriguing paradigm of oxygen‐irrelevant nanoplatform for AMF‐initiated synergistic cancer treatment.

中文翻译：

工程氧无关自由基纳米发电机用于缺氧非依赖性磁热力学肿瘤纳米治疗

肿瘤缺氧显着降低了氧相关治疗方式的治疗效果，因为氧相关抗癌方式中活性氧的产生高度依赖于肿瘤组织中的氧水平。该研究开发了一种独特的磁热力学抗癌策略，该策略利用磁热可分解引发剂产生的与氧无关的自由基在体外诱导癌细胞凋亡和在体内抑制肿瘤。_{自由基纳米发电机是通过在超顺磁性Mn和Co掺杂纳米粒子（MnFe 2} O ₄ @CoFe ₂ O ₄）表面上的介孔二氧化硅涂层的原位工程构建的, 表示为 Mag) 向多功能发展，其中介孔结构为引发剂的有效负载提供了储层，Mag 核心在交变磁场 (AMF) 驱动下用作原位热源。暴露于外源 AMF 后，超顺磁核的磁热疗效应导致负载/递送引发剂 (AIPH) 快速分解，产生与氧无关的自由基。在 AMF 驱动下，磁热效应和有毒自由基的产生在促进缺氧肿瘤微环境中的癌细胞死亡和肿瘤抑制方面具有协同作用。这种自由基纳米发电机的显着治疗功效代表了一种与氧无关的纳米平台的有趣范例，用于 AMF 引发的协同癌症治疗。

更新日期：2021-01-18

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