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Electrolyte‐Triggered C5‐Selective Trifluoromethylation and Halogenation of 8‐Aminoquinoline Derivatives
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2021-01-18 , DOI: 10.1002/ajoc.202000650
Kai Wang 1 , Jiahao Hou 2 , Yangjing Lv 2 , Tingting Wei 2 , Renren Bai 2 , Yuanyuan Xie 3
Affiliation  

An efficient electrolyte‐triggered trifluoromethylation and halogenation at C5 position of 8‐aminoquinoline derivatives was developed, affording the C−H functionalization products in moderate to excellent yields. Furthermore, the mild and green reactions had lower energy consumption and shorter times. Most importantly, both transition‐metal catalysts and oxidants were avoided.

中文翻译:

电解质引发的8-氨基喹啉衍生物的C5选择性三氟甲基化和卤化

开发了一种高效的电解质引发的8-氨基喹啉衍生物的C5位三氟甲基化和卤化,以中等至优异的产率提供了CH功能化产物。此外,温和绿色反应具有较低的能耗和较短的时间。最重要的是,避免使用过渡金属催化剂和氧化剂。
更新日期:2021-03-11
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