This study was designed to evaluate the feasibility of using oils extracted from seeds of soursop industrial waste for use as pharmaceutical ingredients. For that, soursop seeds were subjected to different processes of extraction of fixed oil, by chemical and mechanical routes. After characterization of fixed oils, the feasibility of using them as pharmaceutical excipients was explored by preparing creams in which the oils were used as emollient and/or antioxidant excipient. The oil extracted from soursop seeds in a Soxhlet device and ethyl ether solvent (SFO) showed a yield of 30.72 $\pm$ 0.09 % (w w⁻¹) and, in a domestic extruder (MFO), 23.86 $\pm$ 0.78 % (w w⁻¹). These oils showed physicochemical attributes that indicative of good preservation. The major fatty acid was the oleic acid, with 42.94–43.73 % in relative area, followed by linoleic with 29.5%–30% in relative area. In the non-grease fraction, the SFO showed considerable levels of phenolics (194.5 ± 31.1 mg kg⁻¹) and tocopherols (608.2 ± 36.7 mg kg⁻¹), which gave it an antioxidant potential, confirmed by the 2,2-diphenyl-1-picrylhydrazyl test, with a concentration effective for 50% inhibition (IC50) of 2.8 mg mL⁻¹. Finally, the evaluation of the quality parameters of the creams, suggests that the use of fixed soursop oils to replace the synthetic ingredients usually incorporated (decyl oleate, liquid petrolatum and butylhydroxytoluene), originated formulations with adequate physical and chemical stability. These findings suggest that both oils obtained are possible candidates for use as emollients and antioxidant in pharmaceutical formulas. In addition, contributing to minimize the generation of waste from the fruit agribusiness and add economic value to a by-product generated in the production of fruit pulp.

这项研究旨在评估使用从刺五加工业废料种子中提取的油作为药物成分的可行性。为此，刺五加种子通过化学和机械途径经历了不同的固定油提取过程。在鉴定不挥发性油后，通过制备将油用作润肤剂和/或抗氧化剂的乳膏，探索了将其用作药物赋形剂的可行性。在Soxhlet装置和乙醚溶剂（SFO）中从刺五加种子中提取的油显示出30.72的产率$\pm$0.09％（ww ^-1），而在家用挤出机（MFO）中，为23.86$\pm$0.78％（ww ^-1）。这些油显示出指示良好保存的理化特性。主要脂肪酸为油酸，相对面积为42.94–43.73％，其次为亚油酸，相对面积为29.5％–30％。在非油脂级分中，SFO显示出相当水平的酚类（194.5±31.1 mg kg ^-1）和生育酚（608.2±36.7 mg kg ^-1），这使其具有抗氧化潜力，这一点已由2,2-二苯基证实-1-吡啶甲酰肼试验，对50％抑制（IC50）有效的浓度为2.8 mg mL ^-1。最后，对乳膏的质量参数的评估表明，使用固定的刺五加油代替通常掺入的合成成分（油酸癸酯，液体凡士林和丁基羟基甲苯）可产生具有足够物理和化学稳定性的配方。这些发现表明，获得的两种油都可能在药物配方中用作润肤剂和抗氧化剂。另外，有助于最小化来自水果农业综合企业的废物的产生，并增加了在果肉生产中产生的副产物的经济价值。