High internal phase Pickering emulsions (HIPPEs) have attracted intensive interest for their great potential in foods, cosmetics, and biomedical applications. However, the relatively poor biodegradability and biocompatibility of inorganic and synthetic particulate emulsifiers greatly limit their practical applications. Here, a kind of biobased nanoparticles, namely dialdehyde amylopectin/chitosan complex nanoparticles (DAPCNPs), were fabricated by Schiff base reaction between dialdehyde amylopectin and chitosan with the assistance of ultrasonication treatment. The resultant DAPCNPs were employed to stabilize O/W HIPPEs with various oils, such as toluene, cyclohexane, styrene and edible rapeseed oil. Moreover, the resultant DAPCNPs-stabilized HIPPEs showed high stability under various environmental stresses (80 °C; 20 mM and 100 mM aqueous NaCl solutions). Furthermore, porous scaffolds were also fabricated by freeze-drying cyclohexane-in-water HIPPEs stabilized by DAPCNPs after the introduction of polyvinyl alcohol (PVA) into the continuous phase. These findings would give inspiration for designing polysaccharides-based nanoparticles to stabilize HIPPEs and improve their practical applications.

高内相Pickering乳液（HIPPEs）在食品，化妆品和生物医学应用中的巨大潜力吸引了广泛的兴趣。但是，无机和合成颗粒乳化剂的较差的生物降解性和生物相容性极大地限制了它们的实际应用。在此，借助超声处理，通过二醛支链淀粉与壳聚糖之间的席夫碱反应，制备了一种生物基纳米颗粒，即二醛支链淀粉/壳聚糖复合纳米颗粒（DAPCNPs）。所得的DAPCNP用于将O / W HIPPE与各种油（例如甲苯，环己烷，苯乙烯和食​​用菜籽油）稳定化。此外，所得的DAPCNPs稳定的HIPPE在各种环境应力（80°C； 80°C；20 mM和100 mM NaCl水溶液）。此外，在将聚乙烯醇（PVA）引入连续相后，通过DAPCNPs稳定的水环己烷-环己烷溶液的冷冻干燥，也可以制造多孔支架。这些发现将为设计基于多糖的纳米颗粒以稳定HIPPEs并改善其实际应用提供启发。