Abstract Metal complexes 1–9 have been synthesized by reacting the benzothiazole–pyrazole derivative ligands (L1, L2 and L3) with the metal precursors of ruthenium (Ru), rhodium (Rh) and iridium (Ir). The complexes have been isolated as cationic mononuclear N ∩ N chelating metal complexes having the general formula as [(arene)M(κ 2 (N∩N) -L)Cl]PF 6 where L = L1, L2 and L3, M = Ru, Rh and Ir, arene = p -cymene, Cp*. Structural studies revealed the mode of binding of the ligands to the metal centers is through the nitrogen atom of the benzothiazole ring and the pyrazole nitrogen atom forming a five-membered ring. All these complexes were characterized by various spectroscopic techniques as well as by XRD analysis. These complexes, as well as the ligands, have been investigated for antibacterial and antioxidant activity studies where only a few of the complexes exhibited antibacterial activity against Gram-positive bacterial strains, i.e., Staphylococcus aureus and Bacillus thuringiensis with complex 6 showing the highest bacterial inhibition toward Staphylococcus aureus and complexes 3, 4 and 6 showing the highest inhibition toward Bacillus thuringiensis . While for the antioxidant activity study, all the compounds showed profound antioxidant potency with complexes 6 and 9 showing more the 50% DRSA activity with reference to ascorbic acid (100%) taken as a reference. The antioxidant activity of the complexes is more pronounced as compared to their respective ligands alone. Graphic abstract Benzothiazole–pyrazole derivative ligands upon complexation with the halide bridged metal precursors resulted in the formation of mononuclear N ∩ N chelating complexes. These complexes have been investigated for biological studies such as antibacterial and antioxidant studies, and they arrayed potential response against the bacterial strains under study as well as good antioxidant activity.

中文翻译：

---

一些含有芳烃钌、铑和铱配合物的新型苯并噻唑-吡唑配体的合成和生物学评价

摘要 通过苯并噻唑-吡唑衍生物配体（L1、L2 和 L3）与钌 (Ru)、铑 (Rh) 和铱 (Ir) 的金属前体反应合成了金属配合物 1-9。这些配合物已被分离为阳离子单核 N ∩ N 螯合金属配合物，其通式为 [(芳烃)M(κ 2 (N∩N) -L)Cl]PF 6 其中 L = L1、L2 和 L3，M = Ru、Rh 和 Ir，芳烃 = p-伞花烃，Cp*。结构研究表明，配体与金属中心的结合方式是通过苯并噻唑环的氮原子和吡唑氮原子形成五元环。所有这些配合物都通过各种光谱技术以及 XRD 分析进行表征。这些配合物，以及配体，已经对抗菌和抗氧化活性研究进行了研究，其中只有少数复合物对革兰氏阳性菌株表现出抗菌活性，即金黄色葡萄球菌和苏云金芽孢杆菌，其中复合物 6 对金黄色葡萄球菌和复合物 3、4 和复合物显示出最高的细菌抑制作用图6显示了对苏云金芽孢杆菌的最高抑制。而对于抗氧化活性研究，所有化合物都显示出强大的抗氧化效力，复合物 6 和 9 以抗坏血酸 (100%) 为参照显示出更多的 50% DRSA 活性。与它们各自的单独配体相比，复合物的抗氧化活性更显着。图形摘要苯并噻唑-吡唑衍生物配体与卤化物桥接金属前体络合后形成单核 N ∩ N 螯合配合物。这些复合物已被用于生物学研究，例如抗菌和抗氧化研究，它们排列了对所研究细菌菌株的潜在反应以及良好的抗氧化活性。