The challenges of surviving periods of increased physiological stress elicit selective pressures that drive adaptations to overcome hardships. Bats in the Palearctic region survive winter in hibernation. We sampled single nucleotide polymorphisms (SNPs) in hibernating Myotis myotis bats using double-digest restriction site-associated DNA sequencing and we associated the genomic variability with the observed phenotypes reflecting hibernation site preference, body condition and bat health during hibernation. We did not observe genotype associations between the detrended body condition index, representing fat reserves, and functional genes involved in fat metabolism. Bat body surface temperature, reflecting roost selection, or roost warmth relative to the climate at the site did not show any associations with the sampled genotypes. We found SNPs with associations to macroclimatic variables, characterising the hibernaculum, and blood biochemistry, related to health of the bat. The genes in proximity of the associated SNPs were involved in metabolism, immune response and signal transduction, including chaperones, apoptosis and autophagy regulators and immune signalling molecules. The genetic adaptations included adaptation to tissue repair and protection against tissue damage.

生理压力增加的生存期带来的挑战会产生选择性压力，这些压力会驱使适应能力克服困难。古北地区的蝙蝠在冬眠时可以过冬。我们采样了冬眠的Myotis的Myotis的单核苷酸多态性（SNP）蝙蝠使用双消化限制性位点相关的DNA测序，我们将基因组变异性与观察到的表型相关联，这些表型反映了冬眠位点的偏好，身体状况和冬眠期间的蝙蝠健康状况。我们没有观察到代表脂肪储备的趋势下降的身体状况指数与参与脂肪代谢的功能基因之间的基因型关联。蝙蝠的体表温度反映了栖息地的选择，或者栖息地相对于现场气候的温暖度，与采样的基因型没有任何关联。我们发现单核苷酸多态性与大气候变量相关，表征了蝙蝠的冬眠和血液生物化学，与蝙蝠的健康有关。相关SNPs附近的基因参与了新陈代谢，免疫反应和信号转导，包括伴侣，凋亡和自噬调节剂和免疫信号分子。遗传适应包括对组织修复的适应和对组织损伤的保护。