Ziziphus mauritiana belongs to family of Rhamnaceae, is an improved fast-growing variety of plum and seasonal fruit which is very popular and commonly known as “BAU Kul” in Bangladesh. This study was designed to evaluate the medicinal values of seed and stem bark extracts of Ziziphus mauritiana. Antioxidant, thrombolytic, membrane stabilizing, cytotoxic and antimicrobial activities were characterized using in-vitro methods and anti-diarrheal, analgesic and hypoglycemic activities were evaluated in Swiss albino male mice. The coarse powder of the plant parts were extracted with methanol and methanol portion of the extract was evaporated naturally under room temperature. Then the dried plant extracts were undergone for subsequent investigation. Total phenolic and flavonoid content, and antioxidant capacity of stem bark extract were higher than seed extract. Both extracts had similar DPPH (IC50 of seed 4.53 μg/ml and stem bark 4.13 μg/ml) and NO (IC50 of seed 5.92 μg/ml and stem bark 5.47 μg/ml) free radicals scavenging potential and seed extract was most cytotoxic (LC50 = 1.467 μg/ml). Stem bark extract showed higher thrombolytic and anti-inflammatory potential, and also exhibited 14 mm zone of inhibition against S. aureus. Stem bark extract showed highest anti-diarrheal (75.68% defecation inhibition, p˂ 0.001), analgesic (68.63%writhing inhibition, p˂0.001) and hypoglycemic activity (44.27% blood glucose reduction after 3 h, p˂0.001) at 400 mg/kg body weight dose. This study confirms good medicinal properties of selected plant parts. Further studies on isolation and characterization of its bioactive compounds are highly required.

中文翻译：

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使用体外和体内动物（瑞士白化病雄性小鼠）模型表征Zipziphus mauritiana（BAU Kul）的甲醇种子和茎皮提取物的药理特性

枣（Zipziphus mauritiana）属于鼠李科，是改良的快速生长的李子和时令水果品种，在孟加拉国非常受欢迎，通常称为“ BAU Kul”。本研究旨在评估毛枣（Zipziphus mauritiana）种子和茎皮提取物的药用价值。使用体外方法对抗氧化，血栓溶解，膜稳定，细胞毒性和抗菌活性进行了表征，并对瑞士白化病雄性小鼠的腹泻，镇痛和降糖活性进行了评估。用甲醇提取植物部分的粗粉，提取液的甲醇部分在室温下自然蒸发。然后对干燥的植物提取物进行后续研究。总酚和类黄酮含量，茎皮提取物的抗氧化能力高于种子提取物。两种提取物具有相似的DPPH（种子4.53μg/ ml的IC50和茎皮4.13μg/ ml的IC50）和NO（种子5.92μg/ ml和干皮5.47μg/ ml的IC50）清除自由基的能力，种子提取物对细胞的毒性最大（ LC50 ＝1.467μg/ ml）。茎皮提取物显示出更高的溶栓和抗炎潜力，并且还表现出对金黄色葡萄球菌的14 mm抑制区。茎皮提取物在400 mg时显示最高的止泻（75.68％排便抑制，p˂0.001），止痛药（68.63％扭体抑制，p˂0.001）和降血糖活性（3 h后血糖降低44.27％，p˂0.001）。 / kg体重剂量。这项研究证实了所选植物部位的良好药用特性。