The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) is an intervention that targets common mechanisms that maintain symptoms across multiple disorders. The UP has been shown to be effective across many disorders, including generalized anxiety disorder, major depressive episode (MDE), and panic disorder, that commonly codevelop following trauma exposure. The present study represented the first randomized controlled trial of the UP in the treatment of trauma-related psychopathology, including posttraumatic stress disorder (PTSD), depression, and anxiety symptoms. Adults (N = 43) who developed posttraumatic psychopathology that included PTSD, MDE, or an anxiety disorder after sustaining a severe injury were randomly assigned to receive 10–14 weekly, 60-min sessions of UP (n = 22) or usual care (n = 21). The primary treatment outcome was PTSD symptom severity, with secondary outcomes of depression and anxiety symptom severity and loss of diagnosis for any trauma-related psychiatric disorder. Assessments were conducted at intake, posttreatment, and 6-month follow-up. Posttreatment, participants who received the UP showed significantly larger reductions in PTSD, Hedges’ g = 1.27; anxiety, Hedges’ g = 1.20; and depression symptom severity, Hedges’ g = 1.40, compared to those receiving usual care. These treatment effects were maintained at 6-month follow-up for PTSD, anxiety, and depressive symptom severity. Statistically significant posttreatment loss of PTSD, MDE, and agoraphobia diagnoses was observed for participants who received the UP but not usual care. This study provides preliminary evidence that the UP may be an effective non–trauma-focused treatment for PTSD and other trauma-related psychopathology.

中文翻译：

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情绪障碍跨诊断治疗统一方案治疗创伤后精神病理学疗效的初步研究：一项随机对照试验

情绪障碍跨诊断治疗统一协议 (UP) 是一种干预措施，针对维持多种疾病症状的常见机制。UP 已被证明对许多疾病有效，包括广泛性焦虑症、重度抑郁发作 (MDE) 和恐慌症，这些疾病通常在创伤暴露后共同发展。本研究代表了 UP 治疗创伤相关精神病理学的第一个随机对照试验，包括创伤后应激障碍 (PTSD)、抑郁和焦虑症状。在遭受严重伤害后出现包括 PTSD、MDE 或焦虑症在内的创伤后精神病理学的成年人 ( N = 43) 被随机分配接受每周 10-14 次、每次 60 分钟的 UP ( n= 22) 或常规护理 ( n = 21)。主要治疗结果是 PTSD 症状严重程度，次要结果是抑郁和焦虑症状严重程度以及任何与创伤相关的精神疾病的诊断失败。在摄入、治疗后和 6 个月随访时进行评估。治疗后，接受 UP 的参与者的 PTSD 显着降低，Hedges' g = 1.27；焦虑, Hedges' g = 1.20; 和抑郁症状严重程度，Hedges' g= 1.40，与接受常规护理的人相比。这些治疗效果在 PTSD、焦虑和抑郁症状严重程度的 6 个月随访中保持不变。对于接受 UP 但未接受常规护理的参与者，观察到治疗后 PTSD、MDE 和广场恐惧症诊断的显着损失。这项研究提供了初步证据，表明 UP 可能是一种有效的非创伤重点治疗 PTSD 和其他与创伤相关的精神病理学。