A visible-light-driven self-powered photoelectrochemical (PEC) aptasensor was developed for ampicillin (AMP) detecting based on carbon dots (CDs) hybrid MIL-68(In)-derived In₂O₃In₂S₃ hollow tubular heterojunction (CDs/In₂O₃In₂S₃). In₂S₃ nanosheets uniformly grew in-situ on the surface of In₂O₃ hollow tubes, forming a close contact heterogeneous interface, which significantly promoted the transfer and separation of photo-generated carriers, and provided a large specific surface area and rich active sites for the PEC aptasensing platform. Furthermore, the CDs/In₂O₃In₂S₃/ITO electrode, which was obtained by dipping assembly, showed remarkable and stable photoelectric signals at zero-bias under visible light irradiation. The amino-functionalized AMP aptamer was fixed on the working electrode as a biological recognition element, and the concentration of AMP was determined by observing the change in photocurrent intensity caused by the specific capture of AMP molecules in solution. Under optimized conditions, the developed PEC aptasensor displayed a relatively wide linear range from 0.001 ng mL⁻¹ to 300 ng mL⁻¹, as well as a low detection limit (LOD) of 0.06 pg mL⁻¹. Besides, the novel self-powered PEC AMP-aptasensor exhibited excellent reproducibility, good stability and selectivity, which open a potential avenue for antibiotic residues detection in environmental media.

基于碳点（CD）混合MIL-68（In）衍生的In ₂ O ₃ In ₂ S ₃中空管状异质结（ CD /输入₂ O ₃输入₂ S ₃）。In ₂ S ₃纳米片在In ₂ O ₃表面均匀地原位生长空心管，形成紧密接触的异质界面，显着促进了光生载流子的转移和分离，并为PEC适配平台提供了大的比表面积和丰富的活性位点。此外，CD / In ₂ O ₃ In ₂ S ₃通过浸涂组装获得的/ ITO电极在可见光照射下在零偏压下显示出显着且稳定的光电信号。将氨基官能化的AMP适体作为生物识别元件固定在工作电极上，并通过观察溶液中AMP分子的特异性捕获所引起的光电流强度变化来确定AMP的浓度。在最佳条件下，开发的PEC适体传感器显示出从0.001 ng mL ^-1到300 ng mL ^-1的相对较宽的线性范围，以及0.06 pg mL ^-1的低检测限（LOD）。此外，新型自供电的PEC AMP-适体传感器具有优异的重现性，良好的稳定性和选择性，为在环境介质中检测抗生素残留提供了潜在的途径。