The aim of this study was to identify chemicals migrating from paper-based food packaging materials by GC-Orbitrap mass spectrometry (MS). Migration tests were conducted with samples of butcher paper, liquid egg containers, pizza boxes and pizza box liners. A new approach for an automated data processing of GC-Orbitrap EI data was developed and evaluated with Compound Discoverer™ software. A total of 35 migrated chemicals were putatively identified. They represented natural compounds, fatty acid ethyl esters, FDA substances added to food and Indirect Additives in Food Contact Substances, common phthalates, alkanes, siloxanes, ketones, and chemicals used as additives in packaging. Additionally, some unexpected compounds suspected to be degradation products of additives were identified. Levels of 23 identified chemicals significantly (p < 0.05) changed over the 10-day migration test. For two identified migrants, dibutyl phthalate and benzophenone, calculated specific migration limits (SMLs) were below the established regulatory levels. The information on the identity of chemicals migrating from food packaging materials is important to inform regulatory agencies and to develop risk management strategies.

这项研究的目的是通过GC-Orbitrap质谱（MS）识别从纸质食品包装材料中迁移出来的化学物质。迁移测试是用肉纸，液体鸡蛋容器，比萨盒和比萨盒衬板进行的。开发了一种用于自动处理GC-Orbitrap EI数据的新方法，并使用Compound Discoverer™软件进行了评估。总共鉴定出35种迁移的化学物质。它们代表天然化合物，脂肪酸乙酯，添加到食品中的FDA物质和食品接触物质中的间接添加剂，常见的邻苯二甲酸酯，烷烃，硅氧烷，酮和用作包装中添加剂的化学物质。此外，鉴定了一些疑似为添加剂降解产物的意外化合物。鉴定出的23种化学物质的水平显着（p  <0.05）在10天的迁移测试中发生了变化。对于两个确定的移民，邻苯二甲酸二丁酯和二苯甲酮，计算出的具体移民限量（SML）低于既定的监管水平。有关从食品包装材料中迁移出来的化学品的身份的信息对于告知监管机构和制定风险管理策略很重要。