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Consolidation and generalisation across sleep depend on individual EEG factors and sleep spindle density
Neurobiology of Learning and Memory ( IF 2.2 ) Pub Date : 2021-01-16 , DOI: 10.1016/j.nlm.2021.107384
Alex Chatburn 1 , Kurt Lushington 2 , Mark J Kohler 3
Affiliation  

Sleep is involved in both the consolidation of discrete episodes, as well as the generalisation of acquired memories into schemata. Here, we have isolated early versus late periods of sleep in order to replicate previous behavioural findings and to demonstrate: i) that distinct sleep and sleep electroencephalography (EEG) factors influence the generalisation of learned information, and; ii) that the consolidation and generalisation of memory across sleep depends on individual alpha frequency (IAF) and strength of initial encoding. Subjects underwent a night-half protocol with polysomnography (PSG), and completed a Chinese character-English paired associates learning task. Recognition accuracy of learned word-pairs, the extent to which the subject was able to generalise this knowledge, and the extent of explicit transfer of knowledge were measured. Results demonstrate that quality of initial learning determined the relationship between sleep neurophysiology and outcome, with IAF modulating this effect. We also note an effect of IAF in modulating the effect of sleep spindles in determining generalisation of learned materials. Finally, we note a complex relationship between initial learning, IAF and sleep spindle density in determining when information will reach explicit awareness across sleep. Together, these data implicate encoding factors in subsequent offline processing, demonstrate a potential role for individual differences in the EEG and subsequently add to our understanding of the the conditions in which sleep may benefit both memory and learning.



中文翻译:

整个睡眠的巩固和概括取决于个体 EEG 因素和睡眠纺锤波密度

睡眠既涉及离散事件的巩固,也涉及将获得的记忆概括为图式。在这里,我们分离了早期与晚期睡眠,以复制以前的行为发现并证明:i) 不同的睡眠和睡眠脑电图 (EEG) 因素影响所学信息的泛化,以及;ii) 睡眠中记忆的巩固和泛化取决于个体 alpha 频率 (IAF) 和初始编码的强度。受试者接受了多导睡眠图 (PSG) 的半夜协议,并完成了汉字-英语配对学习任务。测量了所学单词对的识别准确度、受试者能够概括这些知识的程度以及知识显式转移的程度。结果表明,初始学习的质量决定了睡眠神经生理学和结果之间的关系,而 IAF 调节了这种影响。我们还注意到 IAF 在调节睡眠纺锤波在确定学习材料泛化方面的作用。最后,我们注意到初始学习、IAF 和睡眠纺锤波密度之间的复杂关系,以确定信息何时会在整个睡眠中达到明确的意识。总之,这些数据暗示了后续离线处理中的编码因素,证明了 EEG 中个体差异的潜在作用,并随后增加了我们对睡眠可能有益于记忆和学习的条件的理解。IAF 调节这种效果。我们还注意到 IAF 在调节睡眠纺锤波在确定学习材料泛化方面的作用。最后,我们注意到初始学习、IAF 和睡眠纺锤波密度之间的复杂关系,以确定信息何时会在整个睡眠中达到明确的意识。总之,这些数据暗示了后续离线处理中的编码因素,证明了 EEG 中个体差异的潜在作用,并随后增加了我们对睡眠可能有益于记忆和学习的条件的理解。IAF 调节这种效果。我们还注意到 IAF 在调节睡眠纺锤波在确定学习材料泛化方面的作用。最后,我们注意到初始学习、IAF 和睡眠纺锤波密度之间的复杂关系,以确定信息何时会在整个睡眠中达到明确的意识。总之,这些数据暗示了后续离线处理中的编码因素,证明了 EEG 中个体差异的潜在作用,并随后增加了我们对睡眠可能有益于记忆和学习的条件的理解。IAF 和睡眠纺锤波密度确定信息何时会在整个睡眠中达到明确的意识。总之,这些数据暗示了后续离线处理中的编码因素,证明了 EEG 中个体差异的潜在作用,并随后增加了我们对睡眠可能有益于记忆和学习的条件的理解。IAF 和睡眠纺锤波密度确定信息何时会在整个睡眠中达到明确的意识。总之,这些数据暗示了后续离线处理中的编码因素,证明了 EEG 中个体差异的潜在作用,并随后增加了我们对睡眠可能有益于记忆和学习的条件的理解。

更新日期:2021-02-03
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