Development of multifunctional antibacterial agent with long-lasting antibacterial activity and biofilm ablation performance is significant for the effective treatment of bacterial infections. Here, by utilizing the electrostatic interaction between sulfonated chitosan (SCS) and Ag⁺ and chitosan (CS), and the sodium borohydride reduction method, a versatile antibacterial agent (AgNPs@CS/SCS) capable of generating silver nanoparticles (AgNPs) in-situ and long-acting slow-release Ag⁺ was developed. AgNPs@CS/SCS has a good physiological stability and can long-acting slow-release of Ag⁺ due to the pH-dependent Ag⁺ release behavior of AgNPs. Noteworthy, AgNPs@CS/SCS can exert both excellent short- and long-term antibacterial and biofilm ablation activity. Importantly, it also exhibits superior antibacterial activity in the treatment of implant infections, accompanied by good biocompatibility. Together, this study suggest that AgNPs@CS/CSC is indeed a versatile antibacterial agent, and is expected to provide an effective treatment modality for implant infections in the clinic settings.

具有持久抗菌活性和生物膜消融性能的多功能抗菌剂的开发对于有效治疗细菌感染具有重要意义。在此，通过利用磺化壳聚糖（SCS）和Ag之间的静电相互作用⁺和脱乙酰壳多糖（CS），和硼氢化钠还原法，多功能抗菌剂（的AgNPs @ CS / SCS）能够产生银纳米颗粒（的AgNPs）的IN-开发了原位长效缓释Ag ⁺。的AgNPs @ CS / SCS具有良好的生理稳定性和可长效的Ag缓释⁺由于pH依赖性的Ag ⁺AgNP的释放行为。值得注意的是，AgNPs @ CS / SCS可以发挥出色的短期和长期抗菌和生物膜消融活性。重要的是，它在植入物感染的治疗中还表现出卓越的抗菌活性，并具有良好的生物相容性。总之，这项研究表明，AgNPs @ CS / CSC确实是一种多功能的抗菌剂，有望在临床上为植入物感染提供一种有效的治疗方法。