A biocomposite coating comprising chitosan and ZnO deposited on a porous Ti oxide is developed to avoid orthopedic and dental implant-related infections. The coating comprised of an inner layer of nanoporous TiO₂ and the outer layer of the chitosan matrix with ZnO nanoparticles. Microbiological tests show that chitosan coating is effective against Escherichia coli (E. coli), however, its ability to inhibit bacterial adhesion is very limited. A 1.2-fold increase in the antibacterial activity of chitosan/ZnO coating against E. coli was detected as compared to the chitosan coating alone, and the chitosan/ZnO efficiently inhibited biofilm formation. In addition, the chitosan/ZnO coating exhibited improved bioactivity compared to the chitosan coating. The improvement in antibacterial properties and bioactivity of the chitosan/ZnO coating is attributed to the release of Zn²⁺ ions. The critical force of scratching the chitosan/ZnO coating was approximately twice that of the chitosan coating. The potentiodynamic polarization results confirmed that the corrosion resistance of the implant with ZnO/chitosan/Ti structure was improved. In addition, cytocompatibility evaluation indicated that the chitosan/ZnO coating has good cytocompatibility in MG-63 cells as compared to pure Ti.

为了避免骨科和牙科植入物相关的感染，开发了一种包含壳聚糖和ZnO的生物复合涂层，该涂层沉积在多孔氧化钛上。该涂层包括纳米多孔TiO ₂的内层和壳聚糖基质与ZnO纳米颗粒的外层。微生物学测试表明，壳聚糖涂层可有效抵抗大肠杆菌（E. coli），但是其抑制细菌粘附的能力非常有限。壳聚糖/ ZnO涂层对大肠杆菌的抗菌活性提高了1.2倍与单独的壳聚糖涂层相比，检测到的壳聚糖/ ZnO有效抑制了生物膜的形成。另外，与壳聚糖涂层相比，壳聚糖/ ZnO涂层表现出改善的生物活性。壳聚糖/ ZnO涂层的抗菌性能和生物活性的提高归因于Zn ²⁺离子的释放。刮擦壳聚糖/ ZnO涂层的临界力大约是壳聚糖涂层的临界力的两倍。电位动力学极化结果证实，具有ZnO /壳聚糖/ Ti结构的植入物的耐腐蚀性得到改善。另外，细胞相容性评价表明，与纯Ti相比，壳聚糖/ ZnO涂层在MG-63细胞中具有良好的细胞相容性。