Background: SII and SIRI are two novel systemic inflammation indexes that were suggested in predicting poor outcomes in cancers. However, no studies have examined their effect on cardiovascular diseases (CVDs) and all-cause mortality. Thus, this study aims to investigate associations between SII, SIRI, and the risks for CVDs and all-cause mortality.
Methods: A total of 85,154 participants from the Kailuan cohort were included and followed up for incidents of CVDs (including MI, stroke) and all-cause death for 10 years. Multiple Cox regression was used to calculate the adjusted hazard ratios (HRs).
Results: During the follow-up period, 4262 stroke events, 1233 MI events, and 7225 all-cause deaths were identified, respectively. Compared with the lowest quantile (Q1) of SII or SIRI, after adjusted for most cardiovascular risk factors, both indexes showed positive associations with the risk for stroke (adjusted HRs in Q4 were 1.264 (95% CI: 1.157,1.382) for SII, 1.194 (95% CI: 1.087,1.313) for SIRI), and all-cause death (adjusted HRs in Q4 were 1.246 (95% CI: 1.165,1.331) for SII, 1.393 (95% CI: 1.296,1.498) for SIRI). Additionally, higher SII and SIRI are also associated with increased risk of hemorrhagic stroke and ischemic stroke. Higher SIRI but not SII exhibited a higher MI risk, the adjusted HR in Q4 was 1.204 (1.013,1.431). The significant association remained after additional adjustment for CRP. Subgroup analysis and sensitivity analysis displayed consistent results except for SIRI with MI, where the association did not arrive at significance in subjects aged ≥ 60.
Conclusion: Elevated SII and SIRI increased the risk of stroke, two stroke subtypes, and all-cause death. Higher SIRI, but not SII associated with increased MI incidence, and the association of SIRI was only significant in subjects aged < 60.



中文翻译：

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两种新型炎症指数 SII 和 SIRI 与心血管疾病风险和全因死亡率之间的关系：一项针对 85,154 人的十年随访研究

背景： SII 和 SIRI 是两个新的全身炎症指标，被建议用于预测癌症的不良结果。然而，没有研究检查过它们对心血管疾病 (CVD) 和全因死亡率的影响。因此，本研究旨在调查 SII、SIRI 与 CVD 风险和全因死亡率之间的关联。
方法：共纳入开滦队列的 85,154 名参与者，并对 CVD（包括 MI、中风）和全因死亡事件进行为期 10 年的随访。多重 Cox 回归用于计算调整后的风险比 (HR)。
结果：在随访期间，分别确定了 4262 例卒中事件、1233 例 MI 事件和 7225 例全因死亡。与 SII 或 SIRI 的最低分位数 (Q1) 相比，在对大多数心血管危险因素进行调整后，这两个指标均与 SII 的卒中风险呈正相关（Q4 调整后的 HR 为 1.264（95% CI：1.157,1.382））， SIRI 为 1.194（95% CI：1.087,1.313），全因死亡（第四季度调整后的 HR 为 SII 1.246（95% CI：1.165,1.331），SIRI 为 1.393（95% CI：1.296,1.498） ）。此外，较高的 SII 和 SIRI 也与出血性中风和缺血性中风的风险增加有关。较高的 SIRI 但不是 SII 表现出较高的 MI 风险，第 4 季度调整后的 HR 为 1.204 (1.013,1.431)。在对 CRP 进行额外调整后，显着关联仍然存在。
结论： SII 和 SIRI 升高会增加卒中、两种卒中亚型和全因死亡的风险。较高的 SIRI，但与 MI 发病率增加无关，而 SII 与 SIRI 的相关性仅在年龄 < 60 岁的受试者中显着。