Embryonic stem cells (ESCs) can self-renew indefinitely and maintain their pluripotency status. The pluripotency gene regulatory network is critical in controlling these properties and particularly chromatin remodeling complexes. In this review, we summarize the research progresses of the functional and mechanistic studies of BAF complex in mouse ESCs and early embryonic development. A discussion of the mechanistic bases underlying the distinct phenotypes upon the deletion of different BAF subunits in ESCs and embryos will be highlighted.

中文翻译：

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胚胎干细胞中的BAF复合物与早期胚胎发育

胚胎干细胞（ESC）可以无限期自我更新，并保持其多能性状态。多能性基因调控网络对于控制这些特性，尤其是染色质重塑复合物至关重要。在这篇综述中，我们总结了BAF复合物在小鼠胚胎干细胞和早期胚胎发育中的功能和机理研究的研究进展。将着重讨论在ESC和胚胎中不同BAF亚基缺失后不同表型所依据的机制基础。