Abstract Skin cancer (SC) is the most common carcinoma affecting 3 million people annually in the United States and millions of people worldwide. It is classified as melanoma SC (MSC) and non-melanoma SC (NMSC). NMSC represents approximately 80% of SC and includes squamous cell carcinoma and basal cell carcinoma. MSC, however, has a higher mortality rate than SC because of its ability to metastasize. SC is a major health problem in the United States with significant morbidity and mortality in the Caucasian population. Treatment options for SC include cryotherapy, excisional surgery, Mohs surgery, curettage and electrodessication, radiation therapy, photodynamic therapy, immunotherapy, and chemotherapy. Treatment is chosen based on the type of SC and the potential for side effects. Novel targeted therapies are being used with increased frequency for large tumors and for metastatic disease. A scoping literature search on PubMed, Google Scholar, and Cancer Registry websites revealed that traditional chemotherapeutic drugs have little effect against SC after the cancer has metastasized. Following an overview of SC biology, epidemiology, and treatment options, this review focuses on the mechanisms of advanced technologies that use silver nanoparticles in SC treatment regimens.

中文翻译：

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银纳米颗粒在皮肤癌治疗中的治疗策略和潜在影响

摘要 皮肤癌 (SC) 是最常见的癌症，每年影响美国 300 万人和全球数百万人。它分为黑色素瘤SC（MSC）和非黑色素瘤SC（NMSC）。NMSC 约占 SC 的 80%，包括鳞状细胞癌和基底细胞癌。然而，由于 MSC 具有转移能力，其死亡率比 SC 更高。SC 是美国的一个主要健康问题，在白种人群体中发病率和死亡率很高。SC 的治疗选择包括冷冻疗法、切除手术、莫氏手术、刮除术和电干燥、放射疗法、光动力疗法、免疫疗法和化疗。根据 SC 类型和潜在副作用选择治疗方法。新型靶向疗法越来越频繁地用于治疗大型肿瘤和转移性疾病。在 PubMed、Google Scholar 和 Cancer Registration 网站上进行的文献检索显示，传统化疗药物对癌症转移后的 SC 几乎没有作用。在概述 SC 生物学、流行病学和治疗方案之后，本综述重点关注在 SC 治疗方案中使用银纳米粒子的先进技术的机制。