Abstract An N-halamine precursor, namely, 2-amino-5-(2-hydroxyethyl)-6-methylpyrimidin-4-one (AHM), was used as a chain extender in the preparation of a series of N-halamine polyurethane (PU) films, in order to also instill antibacterial properties. The mechanical properties, thermodynamic performance, and antimicrobial performance of the functionalized PU films were systematically studied. The results showed that the addition of AHM could improve the thermodynamic and mechanical properties of the developed PU films. Conducting tests in the presence of Escherichia coli and Staphylococcus aureus as the model microorganisms revealed that prior to chlorination the antibacterial properties of the chlorinated PU-AHM-Cl films improved significantly relative to the analogous films. The excellent antibacterial properties and the overall superior performance of the PU-AHM-Cl films allow their potential application in microbiological protection materials and related fields. Graphical abstract The synthesis and activity of a series of polyurethane (PU) films functionalized with an antibacterial N-halamine precursor (AHM) are reported. The PU-AHM films exhibit excellent thermodynamic and mechanical properties. The chlorinated variants demonstrate superior storage, stability, and antibacterial effects.

中文翻译：

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具有优异抗菌性能的N-卤胺聚氨酯薄膜的制备

摘要 采用 N-卤胺前体，即 2-氨基-5-(2-羟乙基)-6-甲基嘧啶-4-酮 (AHM) 作为扩链剂制备了一系列 N-卤胺聚氨酯。 PU) 薄膜，以增强抗菌性能。系统研究了功能化PU薄膜的机械性能、热力学性能和抗菌性能。结果表明，AHM的加入可以改善所开发的PU薄膜的热力学和机械性能。在存在大肠杆菌和金黄色葡萄球菌作为模型微生物的情况下进行测试表明，在氯化之前，氯化 PU-AHM-Cl 薄膜的抗菌性能相对于类似薄膜显着提高。PU-AHM-Cl薄膜优异的抗菌性能和整体优越的性能使其在微生物防护材料及相关领域具有潜在的应用价值。图形摘要报告了一系列用抗菌 N-卤胺前体 (AHM) 功能化的聚氨酯 (PU) 薄膜的合成和活性。PU-AHM 薄膜表现出优异的热力学和机械性能。氯化变体表现出优异的储存、稳定性和抗菌效果。PU-AHM 薄膜表现出优异的热力学和机械性能。氯化变体表现出优异的储存、稳定性和抗菌效果。PU-AHM 薄膜具有优异的热力学和机械性能。氯化变体表现出优异的储存、稳定性和抗菌效果。