Curcumin, also known as diferuloylmethane, is the main polyphenolic substance present in the rhizomes of Curcuma longa L. This plant showed many beneficial effects and has been used since ancient times for both food and pharmaceutical purposes. Due to its pleiotropic functions, curcumin consumption in the human diet has become very common thanks also to the fact that this natural compound is considered quite safe as it does not have serious side effects. Its functions as an anti-inflammatory, anti-oxidant, neuroprotective, immunomodulatory, anti-toxicant, anti-apoptotic, and anti-diabetic compound are already known and widely demonstrated. There are numerous studies concerning its effects on various human pathologies including cancer, diabetes and arthritis while the studies on curcumin during pregnancy have been performed only in animal models. Data concerning the role of curcumin as anti-inflammatory compound suggest a possible use of curcumin in managing pregnancy complications such as Preeclampsia (PE), Gestational Diabetes Mellitus (GDM), Fetal Growth Restriction (FGR), PreTerm Birth (PTB), and exposure to toxic agents and pathogens. The aim of this review is to present data to support the possible use of curcumin in clinical trials on human gestation complications.

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姜黄素对妊娠结局的多方面作用

姜黄素，也称为二铁甲酰甲烷，是姜黄的根茎中主要的多酚类物质。这种植物显示出许多有益的作用，自古以来就已用于食品和制药目的。由于其多效功能，在人类饮食中食用姜黄素已变得非常普遍，这还归因于这种天然化合物被认为非常安全，因为它没有严重的副作用。其作为抗炎，抗氧化剂，神经保护，免疫调节，抗毒，抗凋亡和抗糖尿病化合物的功能是已知的并得到广泛证明。关于其对各种人类病理学（包括癌症，糖尿病和关节炎）的影响，已有大量研究，而妊娠期姜黄素的研究仅在动物模型中进行。有关姜黄素作为抗炎化合物的作用的数据表明，姜黄素可能用于处理妊娠并发症，例如先兆子痫（PE），妊娠糖尿病（GDM），胎儿生长受限（FGR），早产（PTB）和暴露去毒剂和病原体。这篇综述的目的是提供数据，以支持姜黄素在人类妊娠并发症临床试验中的可能用途。