ABSTRACT

In this study, three different surfaces of Titanium-coated PEEK were compared by their coating strength, cell adhesion, and cell growth, which were produced through electron beam PVD. For this purpose, different samples with smooth, moderate, and coarse roughness surface were prepared. Surface roughness measurement, AFM, SEM, and EDS analyses were applied to compare surface topography, observe the thickness and roughness of the coated surface, and characterised coated materials, respectively. Also, cross-cut, in vitro and in vivo tests were performed to measure adhesion strength and biological differences between samples to validate data on the optimum sample. The results showed that the adhesion strength between the coated layer and the substrate for every sample was reliable, but Cell adhesion for the sample with moderate roughness was the best among all. Therefore, moderate surface roughness was found to be optimum due to the obtained results from the interaction between implant surface and cells.

摘要

在这项研究中，通过电子束 PVD ​​产生的钛涂层 PEEK 的三种不同表面的涂层强度、细胞粘附和细胞生长进行了比较。为此，制备了具有光滑、中等和粗糙表面的不同样品。应用表面粗糙度测量、AFM、SEM 和 EDS 分析来比较表面形貌，观察涂层表面的厚度和粗糙度，并分别表征涂层材料。此外，还进行了横切、体外和体内测试，以测量样品之间的粘附强度和生物学差异，以验证最佳样品的数据。结果表明，每个样品的涂层与基材之间的粘合强度都是可靠的，但中等粗糙度样品的细胞粘附力是最好的。因此，由于从植入物表面和细胞之间的相互作用获得的结果，发现适度的表面粗糙度是最佳的。