Journal of Asian Natural Products Research ( IF 1.3 ) Pub Date : 2021-01-16 , DOI: 10.1080/10286020.2020.1866559 Chuan Tian 1 , Han Gao 1 , Xiao-Ping Peng 1 , Gang Li 1 , Hong-Xiang Lou 1, 2
Abstract
Fusidic acid, a representative member of fungal fusidane triterpenoids, has been clinically used as an antibiotic. In the present study, fusidic acid (1), and its known analogs 16-desacetylfusidic acid (2) and 3β,20-dihydroxy-protosta-16,24-dien-29-oic acid (4), together with one new derivative acremonidiol A (3), were isolated from the endophytic fungus, Acremonium pilosum F47. Their structures were determined by MS and NMR. The spectroscopic data of 2 are firstly reported here. The antibacterial efficacies of 1-4 were evaluated against four selected Gram-positive or Gram-negative bacteria. As expected, only compound 1 showed strong inhibitory effect on Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis.
中文翻译:
来自内生真菌 Acremonium pilosum F47 的夫西地酸衍生物
摘要
夫西地酸是真菌夫西烷三萜类化合物的代表性成员,已在临床上用作抗生素。在本研究中,夫西地酸 ( 1 ) 及其已知类似物 16-脱乙酰夫西地酸 ( 2 ) 和 3 β ,20-dihydroxy-protosta-16,24-dien-29-oic acid ( 4 ),以及一种新的从内生真菌Acremonium pilosum F47中分离出衍生的 acremonidiol A ( 3 ) 。它们的结构由MS和NMR确定。这里首先报道了2的光谱数据。抗菌功效1 - 4对四种选定的革兰氏阳性或革兰氏阴性细菌进行了评估。正如预期的那样,只有化合物1对革兰氏阳性菌金黄色葡萄球菌和枯草芽孢杆菌表现出很强的抑制作用。