In a biorefinery process, 5-Hydroxymethylfurfural (HMF) is a promising biomass-derived chemical with diverse industrial applications. The biotransformation of HMF to different high-valued furanic derivatives, such as 2,5-furandicarboxylic acid, 2,5-diformylfuran, 5-hydroxymethyl-2-furancarboxylic acid, and 5-formyl-2-furancarboxylic acid, has led to the transition from fossil-derived products to bio-based chemicals through sustainable routes. Although, chemocatalytic conversion of HMF has been extensively studied in the recent years, the higher selectivity, environment friendliness, and mild reaction conditions of HMF bioconversion has established these processes as a promising alternative to harsh chemical conditions. To understand the present status and challenges of HMF bioconversion, this review retrospects and describes the recent advancements in the biotransformation of HMF and systematically assesses the recent findings and developments in the HMF biotransformation through various reaction schemes. Further, this review illustrates, in comprehensive detail, the merits and challenges of various biological processes and it proposes a few research trends for economical and facile HMF bioconversion for commercialization. © 2021 Society of Chemical Industry

中文翻译：

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5-羟甲基糠醛生物转化的最新进展：挑战和未来方面

在生物精炼过程中，5-羟甲基糠醛 (HMF) 是一种很有前途的生物质衍生化学品，具有多种工业应用。HMF 生物转化为不同的高价值呋喃衍生物，如 2,5-呋喃二甲酸、2,5-二甲酰基呋喃、5-羟甲基-2-呋喃甲酸和 5-甲酰基-2-呋喃甲酸，导致通过可持续途径从化石衍生产品过渡到生物基化学品。尽管近年来 HMF 的化学催化转化得到了广泛的研究，但 HMF 生物转化的更高选择性、环境友好性和温和的反应条件已使这些工艺成为替代苛刻化学条件的有希望的方法。为了了解 HMF 生物转化的现状和挑战，本综述回顾并描述了 HMF 生物转化的最新进展，并通过各种反应方案系统地评估了 HMF 生物转化的最新发现和进展。此外，本综述全面详细地说明了各种生物过程的优点和挑战，并提出了一些经济和简便的 HMF 生物转化以实现商业化的研究趋势。© 2021 化学工业学会 各种生物过程的优点和挑战，并提出了经济和简便的 HMF 生物转化商业化的一些研究趋势。© 2021 化学工业学会 各种生物过程的优点和挑战，并提出了经济和简便的 HMF 生物转化商业化的一些研究趋势。© 2021 化学工业学会