The objective was to conduct a systematic review to evaluate the effects of dietary supplementation with beta-adrenergic agonists on calpains and calpastatin activity in bovine muscle and changes in meat tenderness. A survey was conducted in June 2019 on Science Direct, Web of Science, Scopus, PubMed and Capes Periodicals, using four keyword combinations: agonist and calpain and cattle; agonist and calpain and bovine; agonist and calpain and heifers; agonist and calpain and steers. Thirteen studies were selected, 54% concluded that supplementation with beta-adrenergic agonists increases calpastatin activity, 23% observed increase in their gene expression and 23% reported no effect on activity or expression of this enzyme. Nine studies evaluated the influence of beta-adrenergic agonists supplementation on meat texture and all found an increase in shear force values. There is strong evidence that beta-adrenergic agonists may increase calpastatin activity in the muscle, causing damage to meat tenderness.

中文翻译：

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β-肾上腺素能激动剂、钙蛋白酶系统活性和牛肉质地之间的关系：系统评价

目的是进行系统评价，以评估膳食补充剂β-肾上腺素能激动剂对牛肌肉中钙蛋白酶和钙蛋白酶抑制素活性以及肉嫩度变化的影响。2019 年 6 月，在 Science Direct、Web of Science、Scopus、PubMed 和 Capes Periodicals 上进行了一项调查，使用了四种关键词组合：agonist 和 calpain 和牛；激动剂和钙蛋白酶和牛；激动剂和钙蛋白酶和小母牛；激动剂和钙蛋白酶和转向。选择了 13 项研究，54% 的人得出结论，补充 β-肾上腺素能激动剂会增加钙蛋白酶抑制素的活性，23% 的人观察到其基因表达增加，23% 的人报告对该酶的活性或表达没有影响。九项研究评估了补充 β-肾上腺素能激动剂对肉质的影响，均发现剪切力值增加。有强有力的证据表明，β-肾上腺素能激动剂可能会增加肌肉中的钙蛋白酶抑制素活性，从而导致肉嫩度受损。