Alteration of sphingosine‐1‐phosphate with aging induces contractile dysfunction of colonic smooth muscle cells via Ca2+‐activated K+ channel (BKCa) upregulation,Neurogastroenterology & Motility

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Alteration of sphingosine‐1‐phosphate with aging induces contractile dysfunction of colonic smooth muscle cells via Ca2+‐activated K+ channel (BKCa) upregulation
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2021-01-16 , DOI: 10.1111/nmo.14052
Xiaoxue Shen ₁ , Ling Zhang ₁ , Ling Jiang ₁ , Wenjie Xiong ₁ , Yurong Tang ₁ , Lin Lin ₁ , Ting Yu ₁

Affiliation

Age‐associated changes alter calcium‐activated potassium channel (BK_Ca) expression of colon. Sphingolipids (SLs) are important cell membrane structural components; altered composition of SLs may affect BK_Ca expression. This study investigated the mechanism by which sphingosine‐1‐phosphate (S1P) contributes to age‐associated contractile dysfunction.

中文翻译：

1-磷酸鞘氨醇随衰老的改变通过Ca2+激活的K+通道（BKCa）上调诱导结肠平滑肌细胞的收缩功能障碍

年龄相关的变化改变了结肠的钙激活钾通道（BK _Ca）表达。鞘脂 (SL) 是重要的细胞膜结构成分；SLs 组成的改变可能会影响 BK _{Ca 的}表达。本研究调查了 1-磷酸鞘氨醇 (S1P) 导致与年龄相关的收缩功能障碍的机制。

更新日期：2021-01-16

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