Sequential One‐pot Method for the Synthesis of 4‐(Hydroxymethyl)oxazoles and their Application in Phosphonates Synthesis,Asian Journal of Organic Chemistry

当前位置： X-MOL 学术 › Asian J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Sequential One‐pot Method for the Synthesis of 4‐(Hydroxymethyl)oxazoles and their Application in Phosphonates Synthesis
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2021-01-16 , DOI: 10.1002/ajoc.202000710
Kajol Km ₁ , Ramesh Chintakunta ₂

Affiliation

A sequential one‐pot method for the synthesis of 4‐(hydroxymethyl)oxazoles from readily available benzamides has been developed. Various substituted benzamides well‐tolerated and furnished 4‐(hydroxymethyl)oxazoles in moderate to good yields under the present reaction conditions. In order to demonstrate the usefulness of the present methodology, the resulting 4‐(hydroxymethyl)oxazoles were successfully transformed into its corresponding phosphonates under Michaelis‐Arbuzov reaction conditions. This methodology features a broad substrate scope, step economy, ease of execution, and scalability.

中文翻译：

顺序一锅法合成4-羟甲基恶唑及其在膦酸酯合成中的应用

已经开发了一种顺序一锅法，可以从容易获得的苯甲酰胺中合成4-（羟甲基）恶唑。在目前的反应条件下，各种取代的苯甲酰胺耐受性良好，并以中等至良好的产率提供了4-（羟甲基）恶唑。为了证明本方法的有效性，在Michaelis-Arbuzov反应条件下，将所得的4-（羟甲基）恶唑成功地转化为其相应的膦酸酯。这种方法具有广泛的基板范围，步骤经济，易于执行和可扩展性的特点。

更新日期：2021-03-11

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11