Comorbidities in COVID-19 patients often lead to more severe outcomes. The disease-specific molecular events, which may induce susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, are being investigated. To assess this, we retrieved array-based gene expression datasets from patients of 30 frequently occurring acute, chronic, or infectious diseases. Comparative analyses of the datasets were performed after quantile normalization and log2 transformation. Among the 78 host genes prominently implicated in COVID-19 infection, ACE2 (receptor for SARS-CoV-2) was positively regulated in several cases, namely, leukemia, psoriasis, lung cancer, non-alcoholic fatty liver disease (NAFLD), breast cancer, and pulmonary arterial hypertension (PAH). FURIN was positively regulated in some cases, such as leukemia, psoriasis, NAFLD, lung cancer, and type II diabetes (T2D), while TMPRSS2 was positively regulated in only 3 cases, namely, leukemia, lung cancer, and T2D. Genes encoding various interferons, cytokines, chemokines, and mediators of JAK-STAT pathway were positively regulated in leukemia, NAFLD, and T2D cases. Among the 161 genes that are positively regulated in the lungs of COVID-19 patients, 99–111 genes in leukemia (including various studied subtypes), 77 genes in NAFLD, and 48 genes in psoriasis were also positively regulated. Because of the high similarity in gene expression patterns, the patients of leukemia, NAFLD, T2D, psoriasis, and PAH may need additional preventive care against acquiring SARS-CoV-2 infections. Further, two genes CARBONIC ANHYDRASE 11 (CA11) and CLUSTERIN (CLU) were positively regulated in the lungs of patients infected with either SARS-CoV-2, or SARS-CoV or Middle East Respiratory Syndrome Coronavirus (MERS-CoV).

COVID-19患者的合并症通常导致更严重的后果。目前正在研究可能引起严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）感染的疾病特异性分子事件。为了对此进行评估，我们从30种常见的急性，慢性或传染病患者中检索了基于阵列的基因表达数据集。在分位数归一化和log2转换后进行数据集的比较分析。在与COVID-19感染显着相关的78个宿主基因中，ACE2（SARS-CoV-2的受体）在几种情况下受到正向调节，即白血病，牛皮癣，肺癌，非酒精性脂肪肝疾病（NAFLD），乳腺癌癌症和肺动脉高压（PAH）。富林在某些情况下，如白血病，牛皮癣，NAFLD，肺癌和II型糖尿病（T2D），其被正调控，而在3例白血病，肺癌和T2D中，TMPRSS2被正调控。编码各种干扰素，细胞因子，趋化因子和JAK-STAT介体的基因在白血病，NAFLD和T2D病例中，该途径被正调控。在COVID-19患者的肺中被正调控的161个基因中，白血病（包括各种研究的亚型）中的99-111个基因，NAFLD中的77个基因和牛皮癣中的48个基因也被正调控。由于基因表达模式的高度相似性，白血病，NAFLD，T2D，牛皮癣和PAH患者可能需要采取其他预防措施来预防SARS-CoV-2感染。此外，在感染了SARS-CoV-2或SARS-CoV或中东呼吸综合征冠状病毒（MERS-CoV）的患者的肺中，正向调节了两个基因CARBONIC ANHYDRASE 11（CA11）和CLUSTERIN （CLU）。