Currently, upconversion nanoparticles (UCNPs) implanted as a contrast agent for optical coherence tomography (OCT) system due to its biocompatibility, anti-stock emission, narrow emission bandwidth non-photobleaching effects etc., but it was not used as multi model imaging probe. We synthesized multimodal imaging probe having upconversion property along with paramagnetic property and used as dual contrast agents for Photothermal Optical Coherence Tomography (PTOCT) and Magnetomotive Optical Coherence Tomography (MMOCT). The synthesized Gd₂O₃:Er³⁺/Yb³⁺ UCNPs shows the bright yellow upconversion emission, biocompatibility with hydrophilic property. A custom built SSOCT setup modified for PTOCT and MMOCT imaging along with custom MATLAB algorithm for signal extraction. A dynamic study was performed with synthesized UCNPs as an imaging probe and functional OCT system for targeted imaging. This shows the utility of the Gd₂O₃:Er³⁺/Yb³⁺ UCNPs as molecular probe for targeted imaging applications.

目前，上转换纳米粒子（UCNPs）由于其生物相容性、抗库存发射、窄发射带宽非光漂白效应等而被植入作为光学相干断层扫描（OCT）系统的造影剂，但并未用作多模型成像探针. 我们合成了具有上转换特性和顺磁特性的多模态成像探针，并用作光热光学相干断层扫描 (PTOCT) 和磁动光学相干断层扫描 (MMOCT) 的双重造影剂。合成的Gd ₂ O ₃ :Er ³⁺ /Yb ³⁺UCNPs 显示出亮黄色的上转换发射，具有亲水性的生物相容性。为 PTOCT 和 MMOCT 成像修改的定制 SSOCT 设置以及用于信号提取的定制 MATLAB 算法。使用合成的 UCNP 作为成像探针和用于靶向成像的功能 OCT 系统进行动态研究。这显示了 Gd ₂ O ₃ :Er ³⁺ /Yb ³⁺ UCNP 作为分子探针用于靶向成像应用的效用。