The present investigation was aimed to study the antimicrobial profile of Clostridium perfringens isolates in fish samples against 10 commonly used antibiotics. A total of 120 fish samples (60 each of Cyprinus carpio var. communis and Schizothorax niger) caught from different sites of the Dal Lake, Srinagar, India. Using species-specific 16S rRNA gene polymerase chain reaction amplification, 37 (30.8%) fish samples (21 C. carpio var. communis and 16 S. niger) out of 120 were found to be positive for C. perfringens. Antimicrobial resistance study of these positive C. perfringens isolates was done by disc diffusion method. The results revealed a similar pattern of antibiotic resistance in the two fish species where the isolates were sensitive to amoxicillin/clavulanic acid, chloramphenicol and ciprofloxacin while resistant to amikacin, ceftriaxone, metronidazole, norfloxacin and tetracycline. The resistance to antibiotics in C. perfringens isolates from fish is an alarming sign because these broad spectrum antibiotics are commonly used for treatment of the diseases caused by pathogen in humans and livestock.

本研究旨在研究鱼类样品中产气荚膜梭状芽孢杆菌分离株对10种常用抗生素的抗菌谱。共有120个鱼类样本（60每鲤鱼变种群落和裂尼日尔）从达尔湖，斯利那加，印度的不同地点抓获。使用物种特异性16S rRNA基因的聚合酶链式反应扩增，37（30.8％）鱼类样本（21鲤鱼变种群落和16 S.曲霉）总分120被发现为是正的产气荚膜梭菌。这些阳性产气荚膜梭菌的抗药性研究分离是通过圆盘扩散法完成的。结果显示，在两种鱼类中，其分离株对阿莫西林/克拉维酸，氯霉素和环丙沙星敏感，而对阿米卡星，头孢曲松，甲硝唑，诺氟沙星和四环素敏感，对抗生素的耐药性相似。从鱼中产气荚膜梭菌分离物中对抗生素的抗药性是一个令人震惊的信号，因为这些广谱抗生素通常用于治疗人和动物的病原体引起的疾病。