Purpose

The main objective of Repro-Can-OPEN Study Part 2 is to learn more about oncofertility practices in optimum resource settings to provide a roadmap to establish oncofertility best practice models.

Methods

As an extrapolation for oncofertility best practice models in optimum resource settings, we surveyed 25 leading and well-resourced oncofertility centers and institutions from the USA, Europe, Australia, and Japan. The survey included questions on the availability and degree of utilization of fertility preservation options in case of childhood cancer, breast cancer, and blood cancer.

Results

All surveyed centers responded to all questions. Responses and their calculated oncofertility scores showed three major characteristics of oncofertility practice in optimum resource settings: (1) strong utilization of sperm freezing, egg freezing, embryo freezing, ovarian tissue freezing, gonadal shielding, and fractionation of chemo- and radiotherapy; (2) promising utilization of GnRH analogs, oophoropexy, testicular tissue freezing, and oocyte in vitro maturation (IVM); and (3) rare utilization of neoadjuvant cytoprotective pharmacotherapy, artificial ovary, in vitro spermatogenesis, and stem cell reproductive technology as they are still in preclinical or early clinical research settings. Proper technical and ethical concerns should be considered when offering advanced and experimental oncofertility options to patients.

Conclusions

Our Repro-Can-OPEN Study Part 2 proposed installing specific oncofertility programs for common cancers in optimum resource settings as an extrapolation for best practice models. This will provide efficient oncofertility edification and modeling to oncofertility teams and related healthcare providers around the globe and help them offer the best care possible to their patients.

中文翻译：

---

在最佳资源环境中针对常见癌症实施肿瘤生育计划（Repro-Can-OPEN 研究第二部分）：委员会意见

 目的

Repro-Can-OPEN 研究第 2 部分的主要目标是更多地了解最佳资源设置中的肿瘤生育实践，以提供建立肿瘤生育最佳实践模型的路线图。

 方法

作为最佳资源环境下肿瘤生育最佳实践模型的推断，我们调查了来自美国、欧洲、澳大利亚和日本的 25 个领先且资源充足的肿瘤生育中心和机构。该调查包括有关儿童癌症、乳腺癌和血癌的生育力保留方案的可用性和利用程度的问题。

 结果

所有接受调查的中心都回答了所有问题。反应及其计算的肿瘤生育评分显示了最佳资源环境下肿瘤生育实践的三个主要特征：（1）大力利用精子冷冻、卵子冷冻、胚胎冷冻、卵巢组织冷冻、性腺屏蔽以及化疗和放疗的分级； (2) GnRH类似物、卵巢固定术、睾丸组织冷冻和卵母细胞体外成熟(IVM)的前景广阔； (3)新辅助细胞保护药物治疗、人工卵巢、体外精子发生和干细胞生殖技术很少使用，因为它们仍处于临床前或早期临床研究环境。在向患者提供先进的实验性肿瘤生育选择时，应考虑适当的技术和伦理问题。

 结论

我们的 Repro-Can-OPEN 研究第 2 部分建议在最佳资源环境中针对常见癌症安装特定的肿瘤生育计划，作为最佳实践模型的外推。这将为全球肿瘤生育团队和相关医疗保健提供者提供有效的肿瘤生育教育和建模，并帮助他们为患者提供最好的护理。