A composition in the form of liquid polymer substance intended for embolization procedures was studied in in vivo experiment. The preparation was injected to rabbits into the femoral artery and abdominal aorta. The polymer composition exhibited properties previously demonstrated in vitro : strong adhesion to the vascular wall, high plasticity sufficient for embolization of the blood vessels, distal distribution, and the absence of toxic effects. The contrast substance remained in the embolus, which simplified its further localization. The agent underwent nether resorption nor organization. Injection of the agent in a volume of 0.1 ml was sufficient for embolization of an artery with a diameter of 0.1 cm. The polymer composition completely obstructed the vessel without inducing perforation of its wall. During the first day of the experiment, a slight infiltration of surrounding tissues with lymphoid cells was observed. By day 7, total dry necrosis of pelvic limb distal to the injection site was diagnosed. Inflammation of the surrounding tissues was shown histologically and was considered as the body response to impaired circulation and necrosis.

中文翻译：

---

液体栓塞化合物的体内研究

在体内实验中研究了用于栓塞手术的液态聚合物物质形式的组合物。将制剂注射到兔子的股动脉和腹主动脉中。该聚合物组合物表现出先前在体外证明的特性：对血管壁的强粘附、足以栓塞血管的高可塑性、远端分布和无毒性作用。对比物质保留在栓子中，这简化了其进一步定位。特工经历了下界吸收或组织。注射0.1ml体积的药剂足以栓塞直径为0.1cm的动脉。聚合物组合物完全阻塞血管而不引起其壁穿孔。在实验的第一天，观察到淋巴细胞轻微浸润周围组织。到第 7 天，诊断出注射部位远端骨盆肢体完全干性坏死。周围组织的炎症在组织学上显示出来，被认为是对循环受损和坏死的身体反应。