Timely restoration of blood supply following myocardial infarction is critical to save the infarcted myocardium, while reperfusion would cause additional damage. Strontium ions have been shown to promote angiogenesis, but it is unknown whether they can save the damaged myocardium. We report that myocardial ischemia/reperfusion (I/R)–induced functional deterioration and scar formation were notably attenuated by injection of strontium ion–containing composite hydrogels into murine infarcted myocardium at 20 minutes of reperfusion following 60 minutes of ischemia. These beneficial effects were accompanied by reduced cardiomyocyte apoptosis and increased angiogenesis. The effects of strontium ions were further confirmed by the enhanced viability of cardiomyocytes and stimulated angiogenesis in vitro. These findings are the first to reveal the cardioprotective effects of strontium ions against I/R injury, which may provide a new therapeutic approach to ischemic heart disease at a lower cost, with higher stability, and with potentially greater safety.

心肌梗死后及时恢复血液供应对于挽救梗死心肌至关重要，而再灌注会造成额外的损伤。锶离子已被证明可以促进血管生成，但尚不清楚它们是否可以挽救受损的心肌。我们报告说，在缺血 60 分钟后，再灌注 20 分钟，将含锶离子的复合水凝胶注射到小鼠梗塞心肌中，可显着减轻心肌缺血/再灌注 (I/R) 诱导的功能恶化和瘢痕形成。这些有益作用伴随着心肌细胞凋亡减少和血管生成增加。锶离子的作用通过增强心肌细胞的活力和体外刺激的血管生成得到进一步证实。