Inhibition of glutamine metabolism promotes death of senescent cells and improves healthy life span in mice Glutamine has a host of metabolic functions, including biosynthesis, redox maintenance, and chromatin biology. Drugs are currently available to target glutamine and related metabolism. However, the use of these compounds has been limited by finding appropriate applications because the role of glutamine in health and disease is still poorly understood. Some studies have pointed to a limited role of glutamine metabolism in vivo; others have found specific roles in critical areas of biomedical interest, such as the potentiation of immune responses in cancer. On page 265 of this issue, Johmura et al. (1) report a role for glutamine in maintaining the viability of senescent cells and the senescence-associated secretory phenotype, which may be a major factor in the aging process. Thus, targeting glutamine and associated metabolic processes could be an attractive, clinically feasible way to modify the aging process.

中文翻译：

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靶向代谢以影响衰老

谷氨酰胺代谢的抑制促进衰老细胞的死亡并延长小鼠的健康寿命谷氨酰胺具有许多代谢功能，包括生物合成、氧化还原维持和染色质生物学。目前有药物可用于靶向谷氨酰胺和相关代谢。然而，由于谷氨酰胺在健康和疾病中的作用仍然知之甚少，因此这些化合物的使用受到了寻找合适应用的限制。一些研究指出体内谷氨酰胺代谢的作用有限；其他人在生物医学兴趣的关键领域发现了特定的作用，例如增强癌症中的免疫反应。在本期第 265 页上，Johmura 等人。(1) 报告了谷氨酰胺在维持衰老细胞活力和衰老相关分泌表型中的作用，这可能是老化过程中的一个主要因素。因此，靶向谷氨酰胺和相关代谢过程可能是一种有吸引力的、临床上可行的改变衰老过程的方法。