Ca–Si mesoporous nanoparticles with the optimal Ag–Zn ratio inhibit the Enterococcus faecalis infection of teeth through dentinal tubule infiltration: an in vitro and in vivo study,Journal of Materials Chemistry B

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Ca–Si mesoporous nanoparticles with the optimal Ag–Zn ratio inhibit the Enterococcus faecalis infection of teeth through dentinal tubule infiltration: an in vitro and in vivo study
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-12-22 , DOI: 10.1039/d0tb02704a
Qing Sun ₁ , Mengting Duan ₁ , Wei Fan ₁ , Bing Fan ₁

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Enterococcus faecalis is the main cause of refractory root canal infections in human teeth. The control of root canal infection is one of the conditions necessary for the successful treatment of refractory root canal infections. In the present study, nano-scale silver–zinc–calcium–silica particles loaded with different ratios of silver–zinc were successfully prepared (Ag_0.5Zn₃-MCSNs and Ag_0.5Zn₁₀-MCSNs). The release profiles, antibacterial activity against E. faecalis, infiltration depth into dentinal tubules, biocompatibility and effects on dentin microhardness in vitro were investigated. In addition, the antimicrobial effects of the particles against Enterococcus faecalis reinfection were evaluated in vivo in the teeth of beagle dogs. Ag, Zn, Ca and Si were released from Ag–Zn-MCSNs, and the atomic ratio of silver and zinc released can reach the optimal value of 1 : 12 (Ag_0.5Zn₁₀-MCSNs). The particles also showed good biocompatibility and antibacterial activity against Enterococcus faecalis and did not reduce the hardness of dentin. The nanoparticles could be driven into the dentinal tubules of dentin slices by ultrasonic activation. In the root canals of beagle dogs, both Ag_0.5Zn₃-MCSNs and Ag_0.5Zn₁₀-MCSNs demonstrated strong preventive effects against E. faecalis infection. The Ag–Zn–Ca–Si mesoporous nanoparticles may develop into a new effective root canal disinfectant or root canal sealer.

中文翻译：

具有最佳Ag-Zn比的Ca-Si介孔纳米颗粒通过牙本质小管浸润来抑制粪肠球菌的感染：一项体内外研究

粪肠球菌是人牙难治性根管感染的主要原因。根管感染的控制是成功治疗难治性根管感染的必要条件之一。在本研究中，成功制备了负载了不同比例的银锌的银锌锌硅纳米颗粒（Ag _0.5 Zn ₃ -MCSNs和Ag _0.5 Zn ₁₀ -MCSNs）。研究了体外释放情况，对屎肠球菌的抗菌活性，牙本质小管的浸润深度，生物相容性以及对牙本质显微硬度的影响。另外，颗粒的抗微生物作用在比格犬的牙齿中对粪肠球菌的再感染进行了体内评估。Ag-Zn-MCSNs释放出Ag，Zn，Ca和Si，释放出的银和锌的原子比可以达到1:12的最佳值（Ag _0.5 Zn ₁₀ -MCSNs）。该颗粒还显示出对粪肠球菌的良好生物相容性和抗菌活性，并且没有降低牙本质的硬度。可以通过超声活化将纳米颗粒驱入牙本质切片的牙本质小管中。在比格犬的根管中，Ag _0.5 Zn ₃ -MCSNs和Ag _0.5 Zn ₁₀ -MCSNs均显示出强大的预防作用粪肠球菌感染。Ag-Zn-Ca-Si介孔纳米粒子可能发展成为一种新型的有效根管消毒剂或根管封闭剂。

更新日期：2021-01-15

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