The challenges of viral infection have increased in recent decades due to the emergence of resistance, cross-resistance and drying up of antiviral drug discovery. Many neglected tropical viruses including the chikungunya virus, dengue virus & Japanese encephalitis virus have gradually become global pathogens. This has further increased the burden of viral infection which necessitates the continuous development of antiviral therapy. The antiviral chemistry began with the development of thiosemicarbazide derived thiosemicarbazones as antiviral. Although very few thiosemicarbazides have progressed into clinical application, it still inspires antiviral development. During last 3 decades (1990- 2020), several efforts have been made to develop suitable antiviral by using thiosemicarbazide scaffold. Its hybridization with other pharmacophores has been used as a strategy to enhance safety and efficacy. Cyclization and substitution of thiosemicarbazides have also been used to develop potent antiviral. With the ability to form coordinate bonds, thiosemicarbazides have been used either as metal complex or chelator against viruses. This work is an attempt to systematically review the research on the use of thiosemicarbazides as an antiviral scaffold. It also reviews the structure-activity relationship and translational suitability of thiosemicarbazide derived compounds.

由于耐药性，交叉耐药性和抗病毒药物发现的枯竭，近几十年来，病毒感染的挑战不断增加。基孔肯雅病毒，登革热病毒和日本脑炎病毒等许多被忽视的热带病毒已逐渐成为全球病原体。这进一步增加了病毒感染的负担，这需要不断开发抗病毒治疗。抗病毒化学始于硫代氨基脲衍生的硫代氨基脲作为抗病毒剂的开发。尽管极少数硫代氨基脲已进入临床应用，但仍激发了抗病毒的发展。在过去的三十年中（1990年至2020年），通过使用硫代氨基脲支架开发了合适​​的抗病毒药物。它与其他药效团的杂交已被用作增强安全性和功效的策略。硫代氨基脲的环化和取代也已用于开发有效的抗病毒药。具有形成配位键的能力，硫代氨基脲已被用作金属络合物或抗病毒螯合剂。这项工作是试图系统地审查使用硫代氨基脲作为抗病毒支架的研究。它还审查了硫代氨基脲衍生化合物的构效关系和翻译适用性。这项工作是试图系统地审查使用硫代氨基脲作为抗病毒支架的研究。它还审查了硫代氨基脲衍生化合物的构效关系和翻译适用性。这项工作是试图系统地审查使用硫代氨基脲作为抗病毒支架的研究。它还审查了硫代氨基脲衍生化合物的构效关系和翻译适用性。