Mini-Reviews in Medicinal Chemistry ( IF 3.3 ) Pub Date : 2020-11-30 , DOI: 10.2174/1389557520666200807134921 Huihui Ti 1
Traditional Chinese medicine (TCM) or herbs are widely used in the prevention and treatment of viral infectious diseases. However, the underlying mechanisms of TCMs remain largely obscure due to complicated material basis and multi-target therapeutics. TCMs have been reported to display anti-influenza activity associated with immunoregulatory mechanisms by enhancing host antiinfluenza immune responses. Previous studies have helped us understand the direct harm caused by the virus itself. In this review, we have tried to summarize recent progress in TCM-based anti-influenza research on the indirect harmful immune responses caused by influenza viruses. In particular, the phytochemicals from TCMs responsible for molecular mechanisms of action belonging to different classes, including phenolic compounds, flavonoids, alkaloids and polysaccharides, have been identified and demonstrated
中文翻译:
中草药对流感的植物化学特征及其抗炎反应
中药(TCM)或草药广泛用于病毒感染性疾病的预防和治疗。然而,由于复杂的物质基础和多靶点治疗方法,中医的基本机制仍然不清楚。据报道中药通过增强宿主抗流感免疫反应而显示出与免疫调节机制相关的抗流感活性。以前的研究帮助我们了解了病毒本身造成的直接危害。在这篇综述中,我们试图总结基于中医的抗流感研究对流感病毒引起的间接有害免疫反应的最新进展。特别是中药中负责分子作用机理的植物化学物质属于不同类别,包括酚类化合物,类黄酮,生物碱和多糖,