Wound healing has been greatly challenging in different acute and chronic skin injuries. Among them, nonrevascularizable critical limb ischemic ulcers, venous leg ulcers, and diabetic lower limb or extremity ulcers are well-known refractory skin injuries that are difficult to treat. Partly differentiated, progenitor cell-based graft transplantation or direct injection of autologous stem cells might promote the wound healing process. Studies aiming to comprehensively analyze the effects of cell therapy on skin wound healing could provide clinical evidence for skin injury treatment. Different databases were searched for full-text publications on the comparison between cell therapy and regular therapy. Heterogeneity was detected by the I² method, and a fixed effect model was applied for data pooling if heterogeneity was absent. Publication bias was analyzed using a funnel plot, and 10 studies were finally included in this study. After a long-term follow-up, fewer patients underwent major amputation in the cell therapy group, compared with the standard therapy group, and those in the cell therapy group were characterized by a smaller ulcer area. Moreover, there was a significant difference in the wound healing rate between the intervention and control groups. However, pain caused by skin wounds was hardly mitigated by cell therapy in patients with critical limb ischemia. In this study, cell therapy proved effective in decreasing the size of ulcers and improving the wound closure rate. Additionally, the major amputation rate was decreased in the cell therapy group. However, the symptoms of pain were hardly alleviated by cell therapy in patients with cutaneous ulcers caused by peripheral artery disease-related critical limb ischemia.

中文翻译：

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细胞疗法对慢性皮肤伤口愈合的综合分析：荟萃分析

在不同的急性和慢性皮肤损伤中，伤口愈合具有很大的挑战性。其中，不可血运重建的严重肢体缺血性溃疡、下肢静脉性溃疡和糖尿病性下肢或四肢溃疡是众所周知的难治性皮肤损伤。部分分化的、基于祖细胞的移植物移植或直接注射自体干细胞可能会促进伤口愈合过程。旨在全面分析细胞疗法对皮肤伤口愈合影响的研究可为皮肤损伤治疗提供临床依据。在不同的数据库中搜索了有关细胞疗法和常规疗法之间比较的全文出版物。I ²检测到异质性方法，如果不存在异质性，则应用固定效应模型进行数据汇集。采用漏斗图分析发表偏倚，最终纳入10项研究。经过长期随访，与标准治疗组相比，细胞治疗组进行大截肢的患者较少，细胞治疗组的特点是溃疡面积较小。此外，干预组和对照组之间的伤口愈合率存在显着差异。然而，严重肢体缺血患者的皮肤伤口引起的疼痛几乎无法通过细胞疗法缓解。在这项研究中，细胞疗法被证明在减少溃疡大小和提高伤口闭合率方面是有效的。此外，细胞治疗组的主要截肢率降低。然而，