Patients with chronic obstructive pulmonary disease (COPD) are characterized by attenuated pulmonary function and are frequently reported with cognitive impairments, especially memory impairments. The mechanism underlying the memory impairments still remains unclear. We applied resting-state functional magnetic resonance imaging (RS-fMRI) to compare the brain local activities with static and dynamic amplitude of low-frequency fluctuations (sALFF, dALFF) among patients with COPD (n = 32) and healthy controls (HC, n = 30). Compared with HC, COPD patients exhibited decreased sALFF in the right basal ganglia and increased dALFF in the bilateral parahippocampal/hippocampal gyrus. The reduced the left basal ganglia was associated with lower oxygen partial pressure. Besides, the increased dALFF in the left hippocampal/parahippocampal cortex was associated with poor semantic-memory performance and the increased dALFF in the left hippocampal/parahippocampal cortex was associated the forced vital capacity. The present study revealed the abnormal static and dynamic local-neural activities in the basal ganglia and parahippocampal/hippocampal cortex in COPD patient and its relationship with poor lung function and semantic-memory impairments.

中文翻译：

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COPD的异常静态和动态局部神经活动及其与肺功能和认知障碍的关系

慢性阻塞性肺疾病 (COPD) 患者的特点是肺功能减弱，经常报告有认知障碍，尤其是记忆障碍。记忆障碍的潜在机制仍不清楚。我们应用静息状态功能磁共振成像 (RS-fMRI) 来比较 COPD 患者 (n = 32) 和健康对照组 (HC, n = 30）。与HC相比，COPD患者右侧基底节sALFF减少，双侧海马旁/海马回dALFF增加。左基底节减少与氧分压降低有关。除了，左海马/海马旁皮层dALFF增加与语义记忆能力差有关，左海马/海马旁皮层dALFF增加与用力肺活量有关。本研究揭示了COPD患者基底节和海马旁/海马皮层的异常静态和动态局部神经活动及其与肺功能差和语义记忆障碍的关系。