Mood disorder patients have greater suicide risk than members of the general population, but how suicidal behavior relates to brain functions has not been fully elucidated. This study investigated how functional connectivity (FC) values between the right/left amygdala and the whole brain relate to suicidal behavior in patients with mood disorder. The participants in this study were 100 mood disorder patients with suicidal behavior (SB group), 120 mood disorder patients with non-suicidal behavior (NSB group), and 138 age- and gender-matched healthy controls (HC group). Whole-brain FC values among the three groups were compared using an analysis of covariance (ANCOVA). Compared to the NSB and HC groups, increased FC values in the right amygdala-bilateral paracentral lobule/precuneus circuit were observed in the SB group (Bonferroni-corrected, p < 0.017). The FC values in the NSB group did not differ significantly from those in the HC group (Bonferroni-corrected, p > 0.017). Moreover, there were no significant differences in FC values between mood disorder patients with suicide attempt (SA group) and mood disorder patients with suicidal ideation (SI group), while the FC values between the right amygdala and bilateral paracentral lobule/precuneus in the SA group were higher than the mean in the SI group. These findings suggest that right amygdala-paracentral lobule/precuneus dysfunction has an important role in patients with mood disorder and suicidal behavior.

中文翻译：

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与情绪障碍和自杀行为患者相关的杏仁核-旁中央小叶/楔前叶功能连接增加

情绪障碍患者比一般人群有更大的自杀风险，但尚未完全阐明自杀行为与大脑功能之间的关系。这项研究调查了右/左杏仁核和整个大脑之间的功能连接 (FC) 值如何与情绪障碍患者的自杀行为相关。本研究的参与者为 100 名有自杀行为的情绪障碍患者（SB 组）、120 名有非自杀行为的情绪障碍患者（NSB 组）和 138 名年龄和性别匹配的健康对照（HC 组）。使用协方差分析 (ANCOVA) 比较三组之间的全脑 FC 值。与 NSB 和 HC 组相比，在 SB 组中观察到右侧杏仁核-双侧中央旁小叶/楔前叶回路的 FC 值增加（Bonferroni 校正，p < 0.017）。NSB 组的 FC 值与 HC 组的 FC 值没有显着差异（Bonferroni 校正，p > 0.017）。此外，有自杀企图的心境障碍患者（SA组）和有自杀意念的心境障碍患者（SI组）之间的FC值没有显着差异，而右侧杏仁核和双侧中央旁小叶/前叶前叶的FC值在SA组之间没有显着差异。组均高于 SI 组的平均值。这些发现表明，右侧杏仁核-中央旁小叶/楔前叶功能障碍在情绪障碍和自杀行为患者中具有重要作用。有自杀企图的心境障碍患者（SA组）与有自杀意念的心境障碍患者（SI组）的FC值无显着差异，而SA组右侧杏仁核与双侧中央旁小叶/前叶的FC值分别为高于 SI 组的平均值。这些发现表明，右侧杏仁核-中央旁小叶/楔前叶功能障碍在情绪障碍和自杀行为患者中具有重要作用。有自杀企图的心境障碍患者（SA组）与有自杀意念的心境障碍患者（SI组）的FC值无显着差异，而SA组右侧杏仁核与双侧中央旁小叶/前叶的FC值分别为高于 SI 组的平均值。这些发现表明，右侧杏仁核-中央旁小叶/楔前叶功能障碍在情绪障碍和自杀行为患者中具有重要作用。