Circadian rhythms are 24-h oscillations driven by a hypothalamic master oscillator that entrains peripheral clocks in almost all cells, tissues and organs. Circadian misalignment, triggered by industrialization and modern lifestyles, has been linked to several pathological conditions, with possible impairment of the quality or even the very existence of life. Living organisms are continuously exposed to air pollutants, and among them, ozone or particulate matters (PMs) are considered to be among the most toxic to human health. In particular, exposure to environmental stressors may result not only in pulmonary and cardiovascular diseases, but, as it has been demonstrated in the last two decades, the skin can also be affected by pollution. In this context, we hypothesize that chronodistruption can exacerbate cell vulnerability to exogenous damaging agents, and we suggest a possible common mechanism of action in deregulation of the homeostasis of the pulmonary, cardiovascular and cutaneous tissues and in its involvement in the development of pathological conditions.

中文翻译：

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昼夜节律放松可能是造成污染的组织损伤的新因素

昼夜节律是由下丘脑主振荡器驱动的24小时振荡，该振荡在几乎所有细胞，组织和器官中携带外围时钟。由工业化和现代生活方式引发的昼夜节律紊乱与多种病理状况有关，可能损害其质量甚至生命的存在。生命有机体不断暴露于空气污染物中，其中臭氧或颗粒物（PMs）被认为对人体健康最具毒性。尤其是，暴露于环境压力因素不仅可能导致肺部疾病和心血管疾病，而且，如最近二十年所证明的那样，皮肤也可能受到污染的影响。在这种情况下，