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Effects of Fruit and Vegetable-Based Nutraceutical on Cognitive Function in a Healthy Population: Placebo-Controlled, Double-Blind, and Randomized Clinical Trial
Antioxidants ( IF 7 ) Pub Date : 2021-01-15 , DOI: 10.3390/antiox10010116
Juan Ángel Carrillo , Raúl Arcusa , María Pilar Zafrilla , Javier Marhuenda

There is scientific evidence of the positive effect of polyphenols from plant foods on cognition, but not enough is known about the synergistic effect when multiple polyphenols are consumed and even less in a healthy non-elderly population. The aim of the present study is to investigate the possible effects of improvements in cognitive function in healthy people as a preparation based on micronized fruit and vegetables consumed. One hundred and eight subjects were selected, stratified by sex in the control intervention group (n = 53) and placebo (n = 55). Volunteers completed the study after two 16-week periods of consumption with a 4-week wash period between each phase. At the beginning and the end of each phase, volunteers performed the Stroop, TESEN, and RIST tests for the measurement of different cognitive function patterns. The results revealed statistically significant differences in all the variables of the tests carried out, especially compared with the placebo. Specially, the results obtained in the Stroop and TESEN test, in addition to the processing speed even with semantic interferences, were markedly better after the treatment with the product under study. Moreover, the consumption of the product under study clearly improves short-term memory, verbal and non-verbal, according to the results obtained in the RIST test. The results showed an improvement in executive function in terms of short-term memory, working memory, selective and sustained attention, and speed of processing.

中文翻译:

基于水果和蔬菜的营养食品对健康人群认知功能的影响:安慰剂对照,双盲和随机临床试验

有科学证据表明,植物性食品中的多酚对认知具有积极作用,但是,当食用多种多酚而在健康的非老年人口中摄入的多酚的协同作用尚不充分时,人们对这种协同作用的了解还不够。本研究的目的是研究基于食用的微粉化水果和蔬菜的制剂对健康人认知功能改善的可能影响。选择了一百零八名受试者,在控制干预组(n = 53)和安慰剂(n= 55)。志愿者经过两个16周的食用期后才完成研究,每个阶段之间要进行4周的清洗。在每个阶段的开始和结束时,志愿者都要进行Stroop,TESEN和RIST测试,以测量不同的认知功能模式。结果显示,在进行的所有测试变量中,统计学上均存在显着差异,尤其是与安慰剂相比。特别是,在Stroop和TESEN测试中获得的结果,除了处理速度(即使存在语义干扰)之外,在使用所研究的产品进行处理之后也明显更好。此外,根据RIST测试获得的结果,所研究产品的食用量明显改善了短期记忆,口头和非语言记忆。
更新日期:2021-01-15
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