Acoustic cardiography can provide simultaneous electrocardiography and acoustic cardiac data to assess the electronic and mechanical heart functions. The aim of this study was to assess whether changes in acoustic cardiographic parameters (ACPs) before and after hemodialysis (HD) are associated with overall and cardiovascular (CV) mortality in HD patients. A total of 162 HD patients was enrolled and ACPs were measured before and after HD, including left ventricular systolic time (LVST), systolic dysfunction index (SDI), third (S3) and fourth (S4) heart sounds, and electromechanical activation time (EMAT). During a follow-up of 2.9 years, 25 deaths occurred with 16 from CV causes. Multivariate analysis showed that high △SDI (per 1; hazard ratio [HR], 2.178; 95% confidence interval [CI], 1.189–3.990), high △EMAT (per 1%; HR, 2.218; 95% CI 1.382–3.559), and low △LVST (per 1 ms; HR, 0.947; 95% CI 0.912–0.984) were independently associated with increased overall mortality. In addition, high △EMAT (per 1%; HR, 2.141; 95% CI 1.117–4.102), and low △LVST (per 1 ms; HR, 0.777; 95% CI 0.637–0.949) were associated with increased CV mortality. In conclusion, the changes in ACPs before and after HD may be a useful clinical marker and stronger prognostic marker of overall and CV mortality than ACPs before HD.

声学心电图可以同时提供心电图和声学心脏数据，以评估电子和机械心脏功能。本研究的目的是评估血液透析 (HD) 前后心声学参数 (ACP) 的变化是否与 HD 患者的总体死亡率和心血管 (CV) 死亡率相关。共纳入 162 例 HD 患者并测量 HD 前后的 ACP，包括左心室收缩时间（LVST）、收缩功能障碍指数（SDI）、第三（S3）和第四（S4）心音以及机电激活时间。 EMAT）。在 2.9 年的随访期间，25 人死亡，其中 16 人死于心血管原因。多变量分析显示，高△ SDI（每 1；风险比 [HR]，2.178；95% 置信区间 [CI]，1.189–3.990）、高△ EMAT（每 1%；HR，2.218；95% CI 1.382–3.559）和低△ LVST（每 1 ms；HR，0.947；95% CI 0.912–0.984）与总体死亡率增加独立相关。此外，高△ EMAT（每 1%；HR，2.141；95% CI 1.117–4.102）和低△ LVST（每 1 ms；HR，0.777；95% CI 0.637–0.949）与心血管死亡率增加相关。总之，与 HD 前的 ACP 相比，HD 前后 ACP 的变化可能是有用的临床标志物，并且是总体死亡率和 CV 死亡率更强的预后标志物。