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Habitual Cannabis Use is Associated with Altered Cardiac Mechanics and Arterial Stiffness, but not Endothelial Function in Young Healthy Smokers
Journal of Applied Physiology ( IF 3.3 ) Pub Date : 2021-01-14 , DOI: 10.1152/japplphysiol.00840.2020
Christian P Cheung 1 , Alexandra M Coates 1 , Philip J Millar 1 , Jamie F Burr 1
Affiliation  

Cigarette smoking is amongst the most detrimental behaviours to cardiovascular health, resulting in arterial stiffening, endothelial dysfunction, and structural/functional alterations to the myocardium. Similar to cigarettes, cannabis is commonly smoked and next to alcohol, is the most commonly used recreational substance in the world. Despite this, little is known about the long-term cardiovascular effects of smoking cannabis. This study explored the associations of cardiovascular structure and function with cannabis use in ostensibly healthy young participants (n=35). Using echocardiography, carotid-femoral pulse wave velocity (cfPWV), and brachial flow-mediated dilation (FMD) we performed a cross-sectional assessment of cardiovascular function in cannabis users (n=18), and controls (n=17). There were no differences in cardiac morphology or traditional resting measures of systolic or diastolic function between cannabis users and controls (all p>0.05); whereas cannabis users demonstrated reduced peak apical rotation compared to controls (cannabis users: 5.5±3.8, controls: 9.6±1.5; p = 0.02). Cannabis users had higher cfPWV compared to controls (cannabis users: 5.8±0.6m/s, controls: 5.3±0.7m/s; p = 0.05), while FMD was similar between cannabis users and controls (cannabis users: 8.3±3.3%, controls: 6.8±3.6%; p= 0.7). Young, healthy, cannabis users demonstrate altered cardiac mechanics and greater aortic stiffness. Further studies should explore causal links between cannabis smoking and altered cardiovascular function.

中文翻译:

习惯使用大麻与年轻健康吸烟者的心脏力学和动脉僵硬度改变有关,但与内皮功能无关

吸烟是对心血管健康最有害的行为之一,可导致动脉僵硬,内皮功能障碍和心肌结构/功能改变。与香烟相似,大麻是经常吸烟的,仅次于酒精,是世界上最常用的娱乐物质。尽管如此,人们对吸烟大麻对心血管的长期影响知之甚少。这项研究探讨了表面上健康的年轻参与者(n = 35)的心血管结构和功能与大麻使用的关系。使用超声心动图,颈股动脉脉搏波速度(cfPWV)和肱动脉血流介导的扩张(FMD),我们对大麻使用者(n = 18)和对照组(n = 17)的心血管功能进行了横断面评估。大麻使用者和对照组之间的心脏形态或传统的收缩或舒张功能静息措施无差异(均p> 0.05);而与对照相比,大麻使用者的顶峰旋转减少了(大麻使用者:5.5±3.8,对照:9.6±1.5; p = 0.02)。大麻使用者的cfPWV高于对照组(大麻使用者:5.8±0.6m / s,对照组:5.3±0.7m / s; p = 0.05),而大麻使用者和对照组之间的口蹄疫相似(大麻使用者:8.3±3.3% ,对照:6.8±3.6%; p = 0.7)。年轻,健康的大麻使用者表现出改变的心脏力学和更大的主动脉僵硬度。进一步的研究应探讨大麻吸烟与心血管功能改变之间的因果关系。而与对照相比,大麻使用者的顶峰旋转减少了(大麻使用者:5.5±3.8,对照:9.6±1.5; p = 0.02)。大麻使用者的cfPWV高于对照组(大麻使用者:5.8±0.6m / s,对照组:5.3±0.7m / s; p = 0.05),而大麻使用者和对照组之间的口蹄疫相似(大麻使用者:8.3±3.3% ,对照:6.8±3.6%; p = 0.7)。年轻,健康的大麻使用者表现出改变的心脏力学和更大的主动脉僵硬度。进一步的研究应探讨大麻吸烟与心血管功能改变之间的因果关系。而与对照相比,大麻使用者的顶峰旋转减少了(大麻使用者:5.5±3.8,对照:9.6±1.5; p = 0.02)。大麻使用者的cfPWV高于对照组(大麻使用者:5.8±0.6m / s,对照组:5.3±0.7m / s; p = 0.05),而大麻使用者和对照组之间的口蹄疫相似(大麻使用者:8.3±3.3% ,对照:6.8±3.6%; p = 0.7)。年轻,健康的大麻使用者表现出改变的心脏力学和更大的主动脉僵硬度。进一步的研究应探讨大麻吸烟与心血管功能改变之间的因果关系。大麻使用者和对照组的口蹄疫相似(大麻使用者:8.3±3.3%,对照组:6.8±3.6%; p = 0.7)。年轻,健康的大麻使用者表现出改变的心脏力学和更大的主动脉僵硬度。进一步的研究应探讨大麻吸烟与心血管功能改变之间的因果关系。大麻使用者和对照组的口蹄疫相似(大麻使用者:8.3±3.3%,对照组:6.8±3.6%; p = 0.7)。年轻,健康的大麻使用者表现出改变的心脏力学和更大的主动脉僵硬度。进一步的研究应探讨大麻吸烟与心血管功能改变之间的因果关系。
更新日期:2021-01-15
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