We refer to an article pointedly titled “CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages” in PNAS (1). This Brief Report addresses a straw man. Thirty years of studies on CSF1 signaling in peripheral populations, assessed via small-molecule inhibitors, antibodies, and mutations, document effects outside of the brain (reviewed in ref. 2). It is nevertheless the case that microglia are unusually dependent on CSF1R signals compared to peripheral macrophage populations. Biallelic loss of function, dominant negative gain of function, and hypomorphic mutations of the CSF1R gene in mice, rats, and humans lead …

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关于CSF1R抑制剂的效用[生物科学]

我们参考了一篇题为“小分子抑制剂对 CSF1R 的抑制不是小胶质细胞特异性的；影响造血和巨噬细胞功能”在 PNAS ( 1 ). 这份简要报告针对一个稻草人。通过小分子抑制剂、抗体和突变评估外周人群中 CSF1 信号传导的 30 年研究，记录了脑外的影响（参见参考文献2）。然而，与外周巨噬细胞群相比，小胶质细胞异常依赖 CSF1R 信号。小鼠、大鼠和人类中CSF1R基因的双等位基因功能丧失、显性负功能增益和亚型突变导致……