Early-life microbiota has been linked to the development of chronic inflammatory diseases. It has been hypothesized that maternal vaginal microbiota is an important initial seeding source and therefore might have lifelong effects on disease risk. To understand maternal vaginal microbiota’s role in seeding the child’s microbiota and the extent of delivery mode-dependent transmission, we studied 665 mother–child dyads from the COPSAC2010 cohort. The maternal vaginal microbiota was evaluated twice in the third trimester and compared with the children’s fecal (at 1 week, 1 month, and 1 year of age) and airway microbiota (at 1 week, 1 month, and 3 months). Based on the concept of weighted transfer ratios (WTRs), we have identified bacterial orders for which the WTR displays patterns indicate persistent or transient transfer from the maternal vaginal microbiome, as well as orders that are shared at later time points independent of delivery mode, indicating a common reservoir.

中文翻译：

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模拟生命早期从母亲到婴儿的阴道微生物群转移

生命早期的微生物群与慢性炎症性疾病的发展有关。据推测，母体阴道微生物群是重要的初始播种来源，因此可能对疾病风险产生终生影响。为了了解母体阴道微生物群在播种儿童微生物群中的作用以及分娩方式依赖性传播的程度，我们研究了来自 COPSAC2010 队列的 665 名母婴二元组。在妊娠晚期对母体阴道微生物群进行了两次评估，并与儿童的粪便（1 周、1 个月和 1 岁）和气道微生物群（1 周、1 个月和 3 个月）进行了比较。基于加权转移比率 (WTR) 的概念，