TonB‐dependent transporters in the Bacteroidetes: Unique domain structures and potential functions,Molecular Microbiology

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TonB‐dependent transporters in the Bacteroidetes: Unique domain structures and potential functions
Molecular Microbiology ( IF 2.6 ) Pub Date : 2021-01-15 , DOI: 10.1111/mmi.14683
Rebecca M Pollet ₁ , Lauryn M Martin ₂ , Nicole M Koropatkin ₃

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The human gut microbiota endows the host with a wealth of metabolic functions central to health, one of which is the degradation and fermentation of complex carbohydrates. The Bacteroidetes are one of the dominant bacterial phyla of this community and possess an expanded capacity for glycan utilization. This is mediated via the coordinated expression of discrete polysaccharide utilization loci (PUL) that invariantly encode a TonB‐dependent transporter (SusC) that works with a glycan‐capturing lipoprotein (SusD). More broadly within Gram‐negative bacteria, TonB‐dependent transporters (TBDTs) are deployed for the uptake of not only sugars, but also more often for essential nutrients such as iron and vitamins. Here, we provide a comprehensive look at the repertoire of TBDTs found in the model gut symbiont Bacteroides thetaiotaomicron and the range of predicted functional domains associated with these transporters and SusD proteins for the uptake of both glycans and other nutrients. This atlas of the B. thetaiotaomicron TBDTs reveals that there are at least three distinct subtypes of these transporters encoded within its genome that are presumably regulated in different ways to tune nutrient uptake.

中文翻译：

拟杆菌中 TonB 依赖性转运蛋白：独特的域结构和潜在功能

人体肠道微生物群赋予宿主多种对健康至关重要的代谢功能，其中之一是复杂碳水化合物的降解和发酵。拟杆菌是该群落的主要细菌门之一，具有扩大的聚糖利用能力。这是通过离散多糖利用位点 (PUL) 的协调表达介导的，该位点不变地编码与聚糖捕获脂蛋白 (SusD) 一起工作的 TonB 依赖性转运蛋白 (SusC)。更广泛地，在革兰氏阴性菌中，TonB 依赖性转运蛋白 (TBDT) 不仅用于摄取糖分，而且更常用于摄取必需营养素，例如铁和维生素。在这里，我们全面了解了模型肠道共生体中发现的 TBDT 库Bacteroides thetaiotaomicron以及与这些转运蛋白和 SusD 蛋白相关的预测功能域范围，用于摄取聚糖和其他营养素。该B. thetaiotaomicron TBDT 的图谱显示，在其基因组中编码的这些转运蛋白至少有三种不同的亚型，可能以不同的方式调节营养吸收。

更新日期：2021-01-15

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