Initially identified in Drosophila, the Hippo signaling pathway regulates how cells respond to their environment by controlling proliferation, migration and differentiation. Many recent studies have focused on characterizing Hippo pathway function and regulation in mammalian cells. Here, we present a brief overview of the major components of the Hippo pathway, as well as their regulation and function. We comprehensively review the studies that have contributed to our understanding of the Hippo pathway in the function of the peripheral nervous system and in peripheral nerve diseases. Finally, we discuss innovative approaches that aim to modulate Hippo pathway components in diseases of the peripheral nervous system.

中文翻译：

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Hippo 通路：周围神经疾病创新治疗的视野

最初在果蝇中发现，Hippo 信号通路通过控制增殖、迁移和分化来调节细胞对环境的反应。最近的许多研究都集中在表征哺乳动物细胞中的 Hippo 通路功能和调节。在这里，我们简要概述了 Hippo 通路的主要组成部分，以及它们的调节和功能。我们全面回顾了有助于我们理解 Hippo 通路在周围神经系统功能和周围神经疾病中的研究。最后，我们讨论了旨在调节外周神经系统疾病中 Hippo 通路成分的创新方法。