Even though sinusoidal quadrupole mass filters have been around for more than 50 years, the relationships defining resolution, resolving power, and transmission from the applied voltages have not been rigorously quantified or discussed. Traditional quadrupole mass filter theory implies that voltages are scanned at constant direct current (DC) to alternating current (AC) voltage ratios with the scanline passing through the origin of the voltage stability diagram. A prominent feature of constant voltage ratio scans is constant baseline theoretical resolving power (m/Δm) that is the same for all masses. Commercial quadrupole instruments rarely scan at constant resolving power because ion transmission increases with mass. Instead, they scan at constant resolution, meaning that the mass window width is fixed. Constant resolution mass scans are preferred because ion transmission does not change with mass. Commercial mass filter systems create constant resolution scans by linearly changing the DC and AC voltages at a fixed ratio in the presence of an additional negative DC voltage offset. This manuscript systematically quantifies the effects of the DC and AC voltages on resolution, resolving power, pseudopotential well depth, and transmission. To quantify these properties, recently developed spreadsheet tools that calculate the laboratory frame stability of ions from the matrix solutions of Hill's equation were used. Voltage scanning methods and their effects on theoretically determined transmission and sensitivity will be discussed.

中文翻译：

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量化正弦质量过滤器的运行

即使正弦四极质量过滤器已经存在了50多年，定义分辨率，分辨能力和来自施加电压的透射率的关系尚未得到严格的量化或讨论。传统的四极杆质量滤波器理论意味着，以恒定的直流（DC）电压与交流（AC）电压比扫描电压，而扫描线则穿过电压稳定性图的原点。恒定电压比扫描的一个突出的特点是恒定的基线理论分辨能力（米/ I”米）对所有群众都是一样的。商用四极杆仪器很少以恒定的分辨力进行扫描，因为离子传输随质量而增加。相反，它们以恒定的分辨率进行扫描，这意味着质量窗口宽度是固定的。优选恒定分辨率的质量扫描，因为离子传输不会随质量变化。商业质量过滤器系统通过在存在附加负DC电压偏移的情况下以固定比例线性更改DC和AC电压来创建恒定分辨率的扫描。该手稿系统地量化了直流和交流电压对分辨率，分辨力，伪势阱深度和传输率的影响。为了量化这些特性，最近开发的电子表格工具可根据Hill's的基质溶液计算离子的实验室框架稳定性 使用s方程。将讨论电压扫描方法及其对理论上确定的透射率和灵敏度的影响。