A Novel and Practical Continuous Flow Chemical Synthesis of Cannabidiol (CBD) and its CBDV and CBDB Analogues,European Journal of Organic Chemistry

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A Novel and Practical Continuous Flow Chemical Synthesis of Cannabidiol (CBD) and its CBDV and CBDB Analogues
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-01-15 , DOI: 10.1002/ejoc.202001633
Elena Chiurchiù ₁ , Susanna Sampaolesi ₂ , Pietro Allegrini ₃ , Daniele Ciceri ₃ , Roberto Ballini ₁ , Alessandro Palmieri ₄

Affiliation

Flow chemical synthesis has been fruitfully used for synthesizing cannabidiol (CBD) and its analogues cannabidivarin (CBDV) and cannabidibutol (CBDB) in 55 %, 56 %, and 59 % yields respectively. This approach permitted both to synthesize products in very short reaction time (residence time 7 minutes) and minimized the formation of psychoactive and illegal cannabinoids such a tetrahydrocannabinol (THC).

中文翻译：

新型实用的连续化学合成大麻二酚（CBD）及其CBDV和CBDB类似物

流动化学合成已被成功地用于合成大麻二酚（CBD）及其类似物大麻素（CBDV）和大麻二丁醇（CBDB），产率分别为55％，56％和59％。这种方法既可以在很短的反应时间内（停留时间为7分钟）合成产物，又可以最大限度地减少精神活性和非法大麻素（如四氢大麻酚（THC））的形成。

更新日期：2021-02-24

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