Temporal orienting in Parkinson’s disease,European Journal of Neuroscience

当前位置： X-MOL 学术 › Eur. J. Neurosci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Temporal orienting in Parkinson’s disease
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2021-01-15 , DOI: 10.1111/ejn.15114
Nahid Zokaei _{1,

2} , Celine R Gillebert _{2,

3} , Joshua J Chauvin _{1,

2} , Daniela Gresch _{1,

2} , Alexander G Board _{1,

2} , Michal Rolinski ₄ , Michele T Hu ₅ , Anna Christina Nobre _{1,

2}

Affiliation

Temporal orienting of attention can affect multiple stages of processing to guide adaptive behaviour. We tested whether temporal expectation in different task contexts is compromised in individuals with Parkinson's disease (PD). In Experiment 1 two temporal‐orienting tasks were used: a speeded task emphasizing motor preparation and a non‐speeded task emphasizing perceptual discrimination using rapid serial visual presentation. In both tasks, auditory cues indicated the likelihood of a target appearing after a short or long interval. In the speeded‐response task, participants used the cues to anticipate an easily detectable target stimulus. In the non‐speeded perceptual‐discrimination task, participants used the cues to help discriminate a target letter embedded in a stream of letters. Relative to healthy participants, participants with PD did not show altered temporal orienting effects in the speeded‐response task. However, they were impaired in using temporal cues to improve perceptual discrimination. In Experiment 2, we tested whether the temporal‐orienting deficits in the perceptual‐discrimination task depended on the requirement to ignore temporally distracting stimuli. We replicated the impaired temporal orienting for perceptual discrimination in an independent group of individuals with PD, and showed the impairment was abolished when individuals were on their dopaminergic medication. In a task without any distracting letters, however, patients off or on medication benefited normally from temporal orienting cues. Our findings suggest that deficits in temporal orienting in individuals with PD interact with specific task demands, such as the requirement to select target from temporally competing distractors.

中文翻译：

帕金森病的时间定向

注意的时间定向可以影响处理的多个阶段以指导适应性行为。我们测试了帕金森病 (PD) 患者在不同任务环境中的时间期望是否受到影响。在实验 1 中，使用了两个时间定向任务：一个强调运动准备的加速任务和一个强调使用快速串行视觉呈现的感知辨别的非加速任务。在这两项任务中，听觉线索表明目标在短或长间隔后出现的可能性。在快速反应任务中，参与者使用提示来预测易于检测的目标刺激。在非加速感知辨别任务中，参与者使用提示来帮助辨别嵌入在字母流中的目标字母。相对于健康的参与者，患有 PD 的参与者在快速反应任务中没有表现出改变的时间定向效应。然而，他们在使用时间线索来改善知觉辨别方面受到损害。在实验 2 中，我们测试了感知辨别任务中的时间定向缺陷是否取决于忽略时间分散刺激的要求。我们在一组独立的 PD 个体中复制了感知歧视的受损时间定向，并表明当个体服用多巴胺能药物时，这种损伤被消除了。然而，在没有任何分散注意力的字母的任务中，停药或服药的患者通常会从时间定向提示中受益。我们的研究结果表明，PD 患者的时间定向缺陷与特定的任务需求相互作用，

更新日期：2021-01-15

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11