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Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy
Advanced Science ( IF 14.3 ) Pub Date : 2021-01-15 , DOI: 10.1002/advs.202003033 Wenxin Liu 1, 2 , Alideertu Dong 1, 2 , Bing Wang 3 , Han Zhang 3
Advanced Science ( IF 14.3 ) Pub Date : 2021-01-15 , DOI: 10.1002/advs.202003033 Wenxin Liu 1, 2 , Alideertu Dong 1, 2 , Bing Wang 3 , Han Zhang 3
Affiliation
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Cancer has been one of the major threats to the lives of human beings for centuries. Traditional therapy is more or less faced with certain defects, such as poor targeting, easy degradation, high side effects, etc. Therefore, in order to improve the treatment efficiency of drugs, an intelligent drug delivery system (DDS) is considered as a promising solution strategy. Due to their special structure and large specific surface area, 2D materials are considered to be a good platform for drug delivery. Black phosphorus (BP), as a new star of the 2D family, is recommended to have the potential to construct DDS by virtue of its outstanding photothermal therapy (PTT), photodynamic therapy (PDT), and biodegradable properties. This tutorial review is intended to provide an introduction of the current advances in BP‐based DDSs for cancer therapy, which covers topics from its construction, classified by the types of platforms, to the stimuli‐responsive controlled drug release. Moreover, their cancer therapy applications including mono‐, bi‐, and multi‐modal synergistic cancer therapy as well as the research of biocompatibility are also discussed. Finally, the current status and future prospects of BP‐based DDSs for cancer therapy are summarized.
中文翻译：
用于癌症治疗的黑磷药物输送系统的最新进展
几个世纪以来，癌症一直是人类生命的主要威胁之一。传统治疗或多或少面临着一定的缺陷，如靶向性差、易降解、副作用大等。因此，为了提高药物的治疗效率，智能药物输送系统（DDS）被认为是一种有前途的治疗方法。解决策略。由于其特殊的结构和大的比表面积，二维材料被认为是良好的药物输送平台。黑磷（BP）作为2D家族的新星，凭借其出色的光热疗法（PTT）、光动力疗法（PDT）和可生物降解特性，被认为具有构建DDS的潜力。本教程综述旨在介绍基于 BP 的 DDS 用于癌症治疗的最新进展，涵盖从其构建（按平台类型分类）到刺激响应控制药物释放的主题。此外，还讨论了它们的癌症治疗应用，包括单模式、双模式和多模式协同癌症治疗以及生物相容性研究。最后，总结了基于BP的DDS用于癌症治疗的现状和未来前景。
更新日期：2021-03-03
中文翻译：
用于癌症治疗的黑磷药物输送系统的最新进展
几个世纪以来，癌症一直是人类生命的主要威胁之一。传统治疗或多或少面临着一定的缺陷，如靶向性差、易降解、副作用大等。因此，为了提高药物的治疗效率，智能药物输送系统（DDS）被认为是一种有前途的治疗方法。解决策略。由于其特殊的结构和大的比表面积，二维材料被认为是良好的药物输送平台。黑磷（BP）作为2D家族的新星，凭借其出色的光热疗法（PTT）、光动力疗法（PDT）和可生物降解特性，被认为具有构建DDS的潜力。本教程综述旨在介绍基于 BP 的 DDS 用于癌症治疗的最新进展，涵盖从其构建（按平台类型分类）到刺激响应控制药物释放的主题。此外，还讨论了它们的癌症治疗应用，包括单模式、双模式和多模式协同癌症治疗以及生物相容性研究。最后，总结了基于BP的DDS用于癌症治疗的现状和未来前景。
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